a theory of rate coding control by intrinsic plasticity effects率编码控制理论内在可塑性的影响.pdfVIP

A Theory of Rate Coding Control by Intrinsic Plasticity Effects ´ 1 2 3 1 J. Naude , J. T. Paz , H. Berry , B. Delord * ` ´ 1 Institut des Systemes Intelligents et de Robotique, CNRS – UMR 7222, Universite Pierre et Marie Curie (UPMC), Paris, France, 2 Department of Neurology Neurological ´ Sciences, Stanford University Medical Center, Stanford, California, United States of America, 3 Project-Team BEAGLE, INRIA Rhone-Alpes, LIRIS UMR5205, Universite de Lyon, Lyon, France Abstract Intrinsic plasticity (IP) is a ubiquitous activity-dependent process regulating neuronal excitability and a cellular correlate of behavioral learning and neuronal homeostasis. Because IP is induced rapidly and maintained long-term, it likely represents a major determinant of adaptive collective neuronal dynamics. However, assessing the exact impact of IP has remained elusive. Indeed, it is extremely difficult disentangling the complex non-linear interaction between IP effects, by which conductance changes alter neuronal activity, and IP rules, whereby activity modifies conductance via signaling pathways. Moreover, the two major IP effects on firing rate, threshold and gain modulation, remain unknown in their very mechanisms. Here, using extensive simulations and sensitivity analysis of Hodgkin-Huxley models, we show that threshold and gain modulation are accounted for by maximal conductance plasticity of conductance that situate in two separate domains of the parameter space corresponding to sub- and supra-threshold