a randomized trial of selenium supplementation and risk of type-2 diabetes, as assessed by plasma adiponectin随机试验的硒补充剂和2型糖尿病的风险,评估的血浆脂联素.pdfVIP

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a randomized trial of selenium supplementation and risk of type-2 diabetes, as assessed by plasma adiponectin随机试验的硒补充剂和2型糖尿病的风险,评估的血浆脂联素.pdf

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a randomized trial of selenium supplementation and risk of type-2 diabetes, as assessed by plasma adiponectin随机试验的硒补充剂和2型糖尿病的风险,评估的血浆脂联素

A Randomized Trial of Selenium Supplementation and Risk of Type-2 Diabetes, as Assessed by Plasma Adiponectin 1 1 2 3,4 Margaret P. Rayman *, Gabrielle Blundell-Pound , Roberto Pastor-Barriuso , Eliseo Guallar , Holger Steinbrenner5, Saverio Stranges6 1 Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom, 2 National Center for Epidemiology, Carlos III Institute of Health and Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain, 3 Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America, 4 National Center for Cardiovascular Research (CNIC), Madrid, Spain, 5 Institute for Biochemistry and Molecular Biology I, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany, 6 Division of Health Sciences, University of Warwick Medical School, Coventry, United Kingdom Abstract Background: Evidence that selenium affects the risk of type-2 diabetes is conflicting, with observational studies and a few randomized trials showing both lower and higher risk linked to the level of selenium intake and status. We investigated the effect of selenium supplementation on the risk of type-2 diabetes in a population of relatively low selenium status as part of the UK PRECISE (PREvention of Cancer by Intervention with SElenium) pilot study. Plasma adiponectin concentration, a recognised independent predictor of type-2 diabetes risk and known to be correlated with circulating selenoprotein P, was the biomarker chosen. Methods: In a randomized, double-blind, placebo-controlled trial, five hundred and one elderly volunteers were randomly assigned to a six-month