a randomised trial of an eight-week, once weekly primaquine regimen to prevent relapse of plasmodium vivax in northwest frontier province, pakistan每周一个八周的随机试验,一旦伯氨喹方案以防止复发的间日疟原虫在西北边境省,巴基斯坦.pdfVIP

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a randomised trial of an eight-week, once weekly primaquine regimen to prevent relapse of plasmodium vivax in northwest frontier province, pakistan每周一个八周的随机试验,一旦伯氨喹方案以防止复发的间日疟原虫在西北边境省,巴基斯坦.pdf

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a randomised trial of an eight-week, once weekly primaquine regimen to prevent relapse of plasmodium vivax in northwest frontier province, pakistan每周一个八周的随机试验,一旦伯氨喹方案以防止复发的间日疟原虫在西北边境省,巴基斯坦

A Randomised Trial of an Eight-Week, Once Weekly Primaquine Regimen to Prevent Relapse of Plasmodium vivax in Northwest Frontier Province, Pakistan 1,2 2 2 2 1 Toby Leslie *, Ismail Mayan , Nasir Mohammed , Panna Erasmus , Jan Kolaczinski , Christopher J. M. Whitty1, Mark Rowland1 1 Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom, 2 HealthNet-TPO, Kabul, Afghanistan Abstract Background: Vivax malaria remains a major cause of morbidity in the subtropics. To undermine the stability of the disease, drugs are required that prevent relapse and provide reservoir reduction. A 14-day course of primaquine (PQ) is effective but cannot safely be used in routine practice because of its interaction with glucose-6-phosphate dehydrogenase (G6PD) deficiency for which testing is seldom available. Safe and effective use of PQ without the need for G6PD testing would be ideal. The efficacy and safety of an 8-week, once weekly PQ regimen was compared with current standard treatment (chloroquine alone) and a 14-day PQ regimen. Methods and Principal Findings: 200 microscopically confirmed Plasmodium vivax patients were randomly assigned to either once weekly 8-week PQ (0.75mg/kg/week), once weekly 8-week placebo, or 14-day PQ (0.5mg/kg/day) in North West Frontier Province, Pakistan. All patients were treated with a standard chloroquine dose and tested for G6PD deficiency. Deficient patients were assigned to the 8-week PQ group. Failure was defined as any subsequent episode of vivax malaria over 11 months of observation. There were 22/71 (31.0%) failures in the placebo group and 1/55 (1.8%) and 4/75 (5.1%) failures in the 14-day and 8-week PQ g