有哪些信誉好的足球投注网站a randomized placebo-controlled trial of acetaminophen for prevention of post-vaccination fever in infants一项随机安慰剂对照试验对乙酰氨基酚预防接种后热的婴儿.pdfVIP
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a randomized placebo-controlled trial of acetaminophen for prevention of post-vaccination fever in infants一项随机安慰剂对照试验对乙酰氨基酚预防接种后热的婴儿
A Randomized Placebo-Controlled Trial of
Acetaminophen for Prevention of Post-Vaccination Fever
in Infants
1 1 1 2 1 1
Lisa A. Jackson *, Do Peterson , John Dunn , Simon J. Hambidge , Maya Dunstan , Patty Starkovich ,
1 1 1 1 1
Onchee Yu , Joyce Benoit , Clara P. Dominguez-Islas , Barbara Carste , Patti Benson , Jennifer C.
Nelson1,3
1 Group Health Research Institute, Seattle, Washington, United States of America, 2 Institute for Health Research, Kaiser Permanente Colorado and Denver Health
Community Health Services, Denver, Colorado, United States of America, 3 Department of Biostatistics, University of Washington, Seattle, Washington, United States of
America
Abstract
Background: Fever is common following infant vaccinations. Two randomized controlled trials demonstrated the efficacy of
acetaminophen prophylaxis in preventing fever after whole cell pertussis vaccination, but acetaminophen prophylaxis has
not been evaluated for prevention of fever following contemporary vaccines recommended for infants in the United States.
Methods: Children six weeks through nine months of age were randomized 1:1 to receive up to five doses of
acetaminophen (10–15 mg per kg) or placebo following routine vaccinations. The primary outcome was a rectal
temperature $38uC within 32 hours following the vaccinations. Secondary outcomes included medical utilization, infant
fussiness, and parents’ time lost from work. Parents could request unblinding of the treatment assignment if the child
developed fever or symptoms that wou
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