有哪些信誉好的足球投注网站a sine-derived element constitutes a unique modular enhancer for mammalian diencephalic fgf8sine-derived元素构成一个独特的模块化增强剂对哺乳动物间脑的fgf8.pdfVIP
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a sine-derived element constitutes a unique modular enhancer for mammalian diencephalic fgf8sine-derived元素构成一个独特的模块化增强剂对哺乳动物间脑的fgf8
A SINE-Derived Element Constitutes a Unique Modular Enhancer for Mammalian Diencephalic Fgf8 1 1 2 1 1¤a Akiko Nakanishi , Naoki Kobayashi , Asuka Suzuki-Hirano , Hidenori Nishihara , Takeshi Sasaki , 3¤b 4 2 1 Mika Hirakawa , Kenta Sumiyama , Tomomi Shimogori , Norihiro Okada * 1 Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Midori-ku, Yokohama, Kanagawa, Japan, 2 RIKEN Brain Science Institute, Hirosawa, Wako City, Saitama, Japan, 3 Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto, Japan, 4 National Institute of Genetics, Mishima, Shizuoka, Japan Abstract Transposable elements, including short interspersed repetitive elements (SINEs), comprise nearly half the mammalian genome. Moreover, they are a major source of conserved non-coding elements (CNEs), which play important functional roles in regulating development-related genes, such as enhancing and silencing, serving for the diversification of morphological and physiological features among species. We previously reported a novel SINE family, AmnSINE1, as part of mammalian-specific CNEs. One AmnSINE1 locus, named AS071, showed an enhancer property in the developing mouse diencephalon. Indeed, AS071 appears to recapitulate the expression of diencephalic fibroblast growth factor 8 (Fgf8). Here we established three independent lines of AS071-transgenic mice and performed detailed expression profiling of AS071- enhanced lacZ in comparison with that of Fgf8 across embryonic stages.
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