有哪些信誉好的足球投注网站a screening pipeline for antiparasitic agents targeting cryptosporidium inosine monophosphate dehydrogenase检查管道的抗寄生虫药物针对隐孢子虫肌苷一磷酸脱氢酶.pdfVIP
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a screening pipeline for antiparasitic agents targeting cryptosporidium inosine monophosphate dehydrogenase检查管道的抗寄生虫药物针对隐孢子虫肌苷一磷酸脱氢酶
A Screening Pipeline for Antiparasitic Agents Targeting Cryptosporidium Inosine Monophosphate Dehydrogenase 1 1 2,3 2 3,4 Lisa Sharling , Xiaoping Liu , Deviprasad R. Gollapalli , Sushil K. Maurya , Lizbeth Hedstrom , Boris Striepen1,5* 1 Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America, 2 Department of Biochemistry, Brandeis University, Waltham, Massachusetts, United States of America, 3 Department of Biology, Brandeis University, Waltham, Massachusetts, United States of America, 4 Department of Chemistry, Brandeis University, Waltham, Massachusetts, United States of America, 5 Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America Abstract Background: The protozoan parasite Cryptosporidium parvum is responsible for significant disease burden among children in developing countries. In addition Cryptosporidiosis can result in chronic and life-threatening enteritis in AIDS patients, and the currently available drugs lack efficacy in treating these severe conditions. The discovery and development of novel anti-cryptosporidial therapeutics has been hampered by the poor experimental tractability of this pathogen. While the genome sequencing effort has identified several intriguing new targets including a unique inosine monophosphate dehydrogenase (IMPDH), pursuing these targets and testing inhibitors has been frustratingly difficult. Methodology and Principal Findings: Here we have developed a pipeline of tools to accelerate the in vivo screening of inhibitors of C. parvum IMPDH. We have genetically engineered the related parasite Toxoplasma gon
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