a novel copper chelate modulates tumor associated macrophages to promote anti-tumor response of t cells一种新型铜螯合调节肿瘤相关巨噬细胞促进肿瘤t细胞的反应.pdfVIP

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2017-09-05 发布于上海
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a novel copper chelate modulates tumor associated macrophages to promote anti-tumor response of t cells一种新型铜螯合调节肿瘤相关巨噬细胞促进肿瘤t细胞的反应.pdf

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a novel copper chelate modulates tumor associated macrophages to promote anti-tumor response of t cells一种新型铜螯合调节肿瘤相关巨噬细胞促进肿瘤t细胞的反应

A Novel Copper Chelate Modulates Tumor Associated Macrophages to Promote Anti-Tumor Response of T Cells 1. 3. 3. 1 Shilpak Chatterjee , Ananda Mookerjee , Jayati Mookerjee Basu , Paramita Chakraborty , Avishek 1 4 5 5 6 Ganguly , Arghya Adhikary , Debanjan Mukhopadhyay , Sudipta Ganguli , Rajdeep Banerjee , 2 2 6 4 5 4 Mohammad Ashraf , Jaydip Biswas , Pradeep K. Das , Gourisankar Sa , Mitali Chatterjee , Tanya Das , Soumitra Kumar Choudhuri1* 1 Department of In Vitro Carcinogenesis and Cellular Chemotherapy, Chittaranjan National Cancer Institute, Kolkata, India, 2 Department of Surgical Oncology, Hospital Unit, Chittaranjan National Cancer Institute, Kolkata, India, 3 INSERM, U-563, CHU Purpan, Toulouse, France, 4 Department of Molecular Medicine, Bose Institute, Kolkata, India, 5 Department of Pharmacology, Institute of Post Graduate Medical Education and Research, Kolkata, India, 6 Rajendra Memorial Research Institute of Medical Sciences, Patna, India Abstract Background: At the early stages of carcinogenesis, the induction of tumor specific T cell mediated immunity seems to block the tumor growth and give protective anti-tumor immune response. However, tumor associated macrophages (TAMs) might play an immunosuppressive role and subvert this anti tumor immunity leading to tumor progression and metastasis. Methodology/Principal Findings: The Cu (II) complex, (chelate), copper N-(2-hydroxy acetophenone) glycinate (CuNG),