有哪些信誉好的足球投注网站a search for trypanosoma brucei rhodesiense diagnostic antigens by proteomic screening and targeted cloning有哪些信誉好的足球投注网站锥虫属brucei rhodesiense诊断抗原的蛋白质组学筛选和有针对性的克隆.pdfVIP
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a search for trypanosoma brucei rhodesiense diagnostic antigens by proteomic screening and targeted cloning有哪些信誉好的足球投注网站锥虫属brucei rhodesiense诊断抗原的蛋白质组学筛选和有针对性的克隆
A Search for Trypanosoma brucei rhodesiense Diagnostic Antigens by Proteomic Screening and Targeted Cloning 1 1,2 3 1 . 2. Theresa Manful , Julius Mulindwa , Fernanda M. Frank , Christine E. Clayton * , Enock Matovu ¨ ¨ 1 Zentrum fur Molekulare Biologie der Universitat Heidelberg, DKFZ-ZMBH Alliance, Heidelberg, Germany, 2 Faculty of Veterinary Medicine, Makerere University, Kampala, ´ ´ ´ Uganda, 3 Catedra de Inmunologıa IDEHU (UBA-CONICET), Facultad de Farmacia y Bioquımica (UBA), Buenos Aires, Argentina Abstract Background: The only available diagnostic method for East African trypanosomiasis is light microscopy of blood samples. A simple immunodiagnostic would greatly aid trypanosomiasis control. Methodology and Principal Findings: To find trypanosome proteins that are specifically recognised by sera from human sleeping sickness patients, we have screened the Trypanosoma brucei brucei proteome by Western blotting. Using cytosolic, cytoskeletal and glycosomal fractions, we found that the vast majority of abundant trypanosome proteins is not specifically recognised by patient sera. We identified phosphoglycerate kinase (PGKC), heat shock protein (HSP70), and histones H2B and H3 as possible candidate diagnostic antigens. These proteins, plus paraflagellar rod protein 1, rhodesain (a cysteine protease), and an extracellular fragment of the Trypanosoma brucei nucleoside transporter TbNT10, were expressed in E. coli and tested for reactivity with patient and control sera. Only TbHSP70
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