有哪些信誉好的足球投注网站a role for nrf2 in redox signalling of the invasive extravillous trophoblast in severe early onset iugr associated with preeclampsia作用在氧化还原信号的侵入性extravillous nrf2滋养层严重早发性iugr与子痫前期相关.pdfVIP
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a role for nrf2 in redox signalling of the invasive extravillous trophoblast in severe early onset iugr associated with preeclampsia作用在氧化还原信号的侵入性extravillous nrf2滋养层严重早发性iugr与子痫前期相关
A Role for Nrf2 in Redox Signalling of the Invasive Extravillous Trophoblast in Severe Early Onset IUGR Associated with Preeclampsia 1 2 1 1 3 Nisreen Kweider *, Berthold Huppertz , Christoph Jan Wruck , Rainer Beckmann , Werner Rath , Thomas Pufe1, Mamed Kadyrov1,4 1 Department of Anatomy and Cell Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany, 2 Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria, 3 Department of Obstetrics and Gynecology, University Hospital of the RWTH, Aachen, Germany, 4 MEDIAN Kliniken, Baden- Wuerttemberg, Germany Abstract Background: Preeclampsia (PE) is characterized by increased lipid oxidation and diminished antioxidant capacity, while intrauterine growth restriction (IUGR) is characterized by impaired invasion of the extravillous trophoblast. Vascular endothelial growth factor (VEGF) has been reported to be altered in preeclampsia. A relationship between VEGF and nuclear factor erythroid 2-related factor-2 (Nrf2) has been shown in vitro, where VEGF prevents oxidative damage via activation of the Nrf2 pathway. In this study the expression of Nrf2, VEGF and 4-hydroxynonenal (4-HNE), was determined in interstitial and endovascular/intramural extravillous trophoblast (EVT) in normal pregnancies and those complicated by severe early onset IUGR associated with preeclampsia IUGR/PE. Materials and Methods: Full-thickness uterine tissues derived from caesarean hysterectomies performed in 5 healthy normotensive women delivering term infants and 6 women with severe early onset IUGR with preeclampsia (29–34 weeks gestation) were analyzed. Interstitial and endovascular extravillous trophoblast were quantified afte
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