有哪些信誉好的足球投注网站a human multi-epitope recombinant vaccinia virus as a universal t cell vaccine candidate against influenza virus人类主要重组痘苗病毒作为一种普适性的t细胞疫苗候选人对抗流感病毒.pdfVIP
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a human multi-epitope recombinant vaccinia virus as a universal t cell vaccine candidate against influenza virus人类主要重组痘苗病毒作为一种普适性的t细胞疫苗候选人对抗流感病毒
A Human Multi-Epitope Recombinant Vaccinia Virus as a Universal T Cell Vaccine Candidate against Influenza Virus 1¤ 1 1,2 1 3 Alan G. Goodman , Paul P. Heinen , Susana Guerra , Aneesh Vijayan , Carlos Oscar S. Sorzano , 1 1 Carmen E. Gomez , Mariano Esteban * ´ ´ 1 Department of Cellular and Molecular Biology, Centro Nacional de Biotecnologıa, Consejo Superior de Investigaciones Cientıficas, Madrid, Spain, 2 Department of ´ ´ Preventative Medicine and Public Health, Universidad Autonoma, Madrid, Spain, 3 Computing Unit, Centro Nacional de Biotecnologıa, Consejo Superior de Investigaciones Cientificas, Madrid, Spain Abstract There is a need to develop a universal vaccine against influenza virus infection to avoid developing new formulations of a seasonal vaccine each year. Many of the vaccine strategies for a universal vaccine target strain-conserved influenza virus proteins, such as the matrix, polymerase, and nucleoproteins, rather than the surface hemagglutinin and neuraminidase proteins. In addition, non-disease-causing viral vectors are a popular choice as a delivery system for the influenza virus antigens. As a proof-of-concept, we have designed a novel influenza virus immunogen based on the NP backbone containing human T cell epitopes for M1, NS1, NP, PB1 and PA proteins (referred a
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