有哪些信誉好的足球投注网站a human trek-1hek cell line a highly efficient screening tool for drug development in neurological diseases人类trek-1hek细胞系的高效筛选工具在神经系统疾病药物开发.pdfVIP
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a human trek-1hek cell line a highly efficient screening tool for drug development in neurological diseases人类trek-1hek细胞系的高效筛选工具在神经系统疾病药物开发
A Human TREK-1/HEK Cell Line: A Highly Efficient Screening Tool for Drug Development in Neurological Diseases ´ Hamid Moha ou Maati, Remi Peyronnet, Christelle Devader, Julie Veyssiere, Fabien Labbal, Carine Gandin, Jean Mazella, Catherine Heurteaux, Marc Borsotto* ´ ´ Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique (CNRS, UMR6097), Universite de Nice Sophia Antipolis, Valbonne, France Abstract TREK-1 potassium channels are involved in a number of physiopathological processes such as neuroprotection, pain and depression. Molecules able to open or to block these channels can be clinically important. Having a cell model for screening such molecules is of particular interest. Here, we describe the development of the first available cell line that constituvely expresses the TREK-1 channel. The TREK-1 channel expressed by the h-TREK-1/HEK cell line has conserved all its modulation properties. It is opened by stretch, pH, polyunsaturated fatty acids and by the neuroprotective molecule, riluzole and it is blocked by spadin or fluoxetine. We also demonstrate that the h-TREK-1/HEK cell line is protected against ischemia by using the oxygen-glucose deprivation model. Citation: Moha ou Maati H, Peyronnet R, Devader C, Veyssiere J, Labbal F, et al. (2011) A Human TREK-1/HEK Cell Line: A Highly Efficient Screening Tool for Drug Development in Neurological Diseases. PLoS ONE 6(10): e25602. doi:10.1371/journal.pone.0025602 Editor: Sven G. Meuth, University of Muenster, Germany Received August 10, 2011; Accepted September 6, 2011; Published October 14, 2011 Copyright: 2011 Moha ou Maati et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, whi
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