有哪些信誉好的足球投注网站a novel anticancer therapy that simultaneously targets aberrant p53 and notch activities in tumors一种新型抗癌疗法,同时目标异常p53和切口活动肿瘤.pdfVIP
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a novel anticancer therapy that simultaneously targets aberrant p53 and notch activities in tumors一种新型抗癌疗法,同时目标异常p53和切口活动肿瘤
A Novel Anticancer Therapy That Simultaneously Targets Aberrant p53 and Notch Activities in Tumors Yuting Yao1,3., Li Wang3., He Zhang1,2, Haibo Wang1,3, Xiaoping Zhao1,3, Yidan Zhang1,3, 1,3 1,3 3 2 1,3 Leilei Zhang , Xianqun Fan , Guanxiang Qian * , Ji-Fan Hu * , Shengfang Ge * 1 Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China, 2 VA Palo Alto Health Care System, Stanford University Medical School, Palo Alto, California, United States of America, 3 Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China Abstract Notch signaling pathway plays an important role in tumorigenesis by maintaining the activity of self-renewal of cancer stem cells, and therefore, it is hypothesized that interference of Notch signaling may inhibit tumor formation and progression. H101 is a recombinant oncolytic adenovirus that is cytolytic in cells lacking intact p53, but it is unable to eradicate caner stem cells. In this study, we tested a new strategy of tumor gene therapy by combining a Notch1-siRNA with H101 oncolytic adenovirus. In HeLa-S3 tumor cells, the combined therapy blocked the Notch pathway and induced apoptosis in tumors that are p53-inactive. In nude mice bearing xenograft tumors derived from HeLa-S3 cells, the combination of H101/Notch1- siRNA therapies inhibited tumor growth. Moreover, Notch1-siRNA increased Hexon gene expression at both the transcriptional and the translational levels, and promoted H101 replication in tumors, thereby enhancing the oncolytic activity of H101. These data demonstrate the feasibility to
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