a high-resolution map of synteny disruptions in gibbon and human genomes高分辨率的地图同线性中断在吉本和人类基因组.pdfVIP

A High-Resolution Map of Synteny Disruptions in Gibbon and Human Genomes 1[* 1[ 1 1 1 2 Lucia Carbone , Gery M. Vessere , Boudewijn F.H. ten Hallers , Baoli Zhu , Kazutoyo Osoegawa , Alan Mootnick , 3 4 5 5 5 6 Andrea Kofler , Johannes Wienberg , Jane Rogers , Sean Humphray , Carol Scott , R. Alan Harris , 6 1 Aleksandar Milosavljevic , Pieter J. de Jong 1 BACPAC Resources, Children’s Hospital of Oakland Research Institute, Oakland, California, United States of America, 2 Gibbon Conservation Center, Santa Clarita, California, United States of America, 3 Chrombios GmbH, Raubling, Germany, 4 Anthropology and Human Genetics, Department of Biology II, Munich University, Munich, Germany, 5 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom, 6 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America Gibbons are part of the same superfamily (Hominoidea) as humans and great apes, but their karyotype has diverged faster from the common hominoid ancestor. At least 24 major chromosome rearrangements are required to convert the presumed ancestral karyotype of gibbons into that of the hominoid ancestor. Up to 28 additional rearrangements distinguish the various living species from the common gibbon ancestor. Using the northern white-cheeked gibbon (2n ¼ 52) (Nomascus leucogenys leucogenys) as a model, we created a high-resolution map of the homologous regions between the gibbon and human. The positions of 100 synteny breakpoints relative to the assembled human genome were determined at a resolution of about 200