a higher correlation of hcv core antigen with cd4+ t cell counts compared with hcv rna in hcvhiv-1 coinfected patients更高的丙肝病毒核心抗原相关性与cd4 + t细胞计数与丙肝病毒rna在hcvhiv-1合并感染患者.pdfVIP

A Higher Correlation of HCV Core Antigen with CD4+ T Cell Counts Compared with HCV RNA in HCV/HIV-1 Coinfected Patients 1. 1. 2 2 3 4 Tao Shen , Xiangmei Chen , Weidong Zhang , Yuanlin Xi , Guanghua Cao , Yuhong Zhi , Shuiwang 4 1 5 1 1 Wang , Chunhui Xu , Lai Wei , Fengmin Lu *, Hui Zhuang * 1 Department of Microbiology and Infectious Disease Center, Peking University Health Science Center, Beijing, China, 2 Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China, 3 Shangcai County People’s Hospital, Shangcai, Henan, China, 4 Shangcai Center for Disease Control and Prevention, Shangcai, Henan, China, 5 Institute of Hepatology, Peking University People’s Hospital, Beijing, China Abstract Development of HCV infection is typically followed by chronic hepatitis C (CHC) in most patients, while spontaneous HCV viral clearance (SVC) occurs in only a minority of subjects. Compared with the widespread application of HCV RNA testing by quantitative RT-PCR technique, HCV core antigen detection may be an alternative indicator in the diagnosis of hepatitis C virus infections and in monitoring the status of infectious individuals. However, the correlation and differences between these two indicators in HCV infection need more investigation, especially in patients coinfected by HIV-1. In this study, a total of 354 anti-HCV and/or anti-HIV serum positive residents from a village of central China were enrolled. Besides HCV- related hepatopathic variables including clinical status, ALT, AST, anti-HCV Abs, as well as the altered CD4+/CD8+ T cell counts, HCV core antigen and HCV viral load were also measured.