有哪些信誉好的足球投注网站a novel animal model of borrelia recurrentis louse-borne relapsing fever borreliosis using immunodeficient mice一种新的动物模型的包柔氏螺旋体传播虱播回归热recurrentis莱姆疏螺旋体病使用免疫缺陷小鼠.pdfVIP
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a novel animal model of borrelia recurrentis louse-borne relapsing fever borreliosis using immunodeficient mice一种新的动物模型的包柔氏螺旋体传播虱播回归热recurrentis莱姆疏螺旋体病使用免疫缺陷小鼠
A Novel Animal Model of Borrelia recurrentis Louse- Borne Relapsing Fever Borreliosis Using Immunodeficient Mice 1 1 2 ¨ 1 Christer Larsson , Jenny Lundqvist , Nico van Rooijen , Sven Bergstrom * ˚ ˚ 1 Umea University, Department of Molecular Biology and Laboratory for Molecular Infection Medicine Sweden (MIMS), Umea, Sweden, 2 Vrije University, Department of Molecular Cell Biology, Amsterdam, The Netherlands Abstract Louse-borne relapsing fever (LBRF) borreliosis is caused by Borrelia recurrentis, and it is a deadly although treatable disease that is endemic in the Horn of Africa but has epidemic potential. Research on LBRF has been severely hampered because successful infection with B. recurrentis has been achieved only in primates (i.e., not in other laboratory or domestic animals). Here, we present the first non-primate animal model of LBRF, using SCID (-B, -T cells) and SCID BEIGE (-B, -T, -NK cells) immunocompromised mice. These animals were infected with B. recurrentis A11 or A17, or with B. duttonii 1120K3 as controls. B. recurrentis caused a relatively mild but persistent infection in SCID and SCID BEIGE mice, but did not proliferate in NUDE (-T) and BALB/c (wild-type) mice. B. duttonii was infectious but not lethal in all animals. These findings demonstrate that the immune response can limit relapsing fever even in the absence of humoral defense mechanisms. To study the significance of phagocytic cells in this context, we induced systemic depletion of such cells in the experimental mice by injecting them with clodronate liposomes, which resulted in uncontrolled B. duttonii growth
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