a non-synonymous single nucleotide polymorphism in an oprm1 splice variant is associated with fentanyl-induced emesis in women undergoing minor gynaecological surgery的非同义单核苷酸多态性oprm1拼接变体与fentanyl-induced呕吐在女性小妇科手术.pdfVIP

A Non-Synonymous Single Nucleotide Polymorphism in an OPRM1 Splice Variant Is Associated with Fentanyl- Induced Emesis in Women Undergoing Minor Gynaecological Surgery 1,2,3 5 2 1,3 5 Grace Su Yin Pang , Farida Ithnin , Yin Yee Wong , Jing Bo Wang , Yvonne Lim , Alex Tiong Heng Sia5, Caroline Guat Lay Lee1,3,4* 1 Liver Cancer Functional Genomics Laboratory, National Cancer Centre Singapore, Singapore, Singapore, 2 Department of Palliative Medicine, National Cancer Centre Singapore, Singapore, Singapore, 3 Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 4 DUKE-NUS Graduate Medical School, Singapore, Singapore, 5 Department of Obstetric Anaesthesia, KK Women’s and Children’s Hospital, Singapore, Singapore Abstract Background: Fentanyl-induced emesis (FIE) is a distressing adverse effect in the postoperative setting. The genetic basis of FIE remains largely unknown, therefore, we examined whether it was associated with specific genetic variants of OPRM1, the gene encoding the main receptor target of fentanyl. Methods: In this prospective case-control study, 193 women undergoing gynaecological surgery under a standardized anaesthetic with a low emetogenic risk were enrolled. Inclusion and exclusion criteria were designed to select extreme phenotypes as well as to ensure that most major confounders for FIE were either excluded or present in all patients. To control for unforeseen intra- and postoperative confounders for FIE, only 161 patients were further analysed, out of which 10 were categorized as having FIE, defined by the presence of at least one of thr