a grfa2prop1stem (gps) cell niche in the pituitarygrfa2prop1stem(gps)垂体细胞利基.pdfVIP

A GRFa2/Prop1/Stem (GPS) Cell Niche in the Pituitary 1 ´ 2 3 4 1 Montse Garcia-Lavandeira , Vıctor Quereda , Ignacio Flores , Carmen Saez , Esther Diaz-Rodriguez , 4 5 3 1,6 2 Miguel A. Japon , Aymee K. Ryan , Maria A. Blasco , Carlos Dieguez , Marcos Malumbres *, Clara V. Alvarez1* 1 Department of Physiology, School of Medicine, University of Santiago de Compostela (USC), Santiago de Compostela, Spain, 2 Cell Division and Cancer Group, Centro ´ Nacional de Investigaciones Oncologicas (CNIO), Madrid, Spain, 3 Telomeres and Telomerase Group, Centro Nacional de Investigaciones Oncologicas (CNIO), Madrid, Spain, 4 Department of Pathology, Hospital Universitario Virgen del Rocio, Seville, Spain, 5 Department of Human Genetics, McGill University (MUHC), Montreal, Quebec, Canada, 6 CIBER Obesity Nutrition (ISCIII), Santiago de Compostela, Spain Abstract Background: The adult endocrine pituitary is known to host several hormone-producing cells regulating major physiological processes during life. Some candidates to progenitor/stem cells have been proposed. However, not much is known about pituitary cell renewal throughout life and its homeostatic regulation during specific physiological changes, such as puberty or pregnancy, or in pathological conditions such as tumor development. Principal Findings: We have identified in rodents and huma