a candidate hivaids vaccine (mva-b) lacking vaccinia virus gene c6l enhances memory hiv-1-specific t-cell responses候选人条件疫苗(mva-b)缺乏牛痘病毒基因c6l增强记忆hiv-1-specific t细胞反应.pdfVIP

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2017-09-05 发布于上海
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a candidate hivaids vaccine (mva-b) lacking vaccinia virus gene c6l enhances memory hiv-1-specific t-cell responses候选人条件疫苗(mva-b)缺乏牛痘病毒基因c6l增强记忆hiv-1-specific t细胞反应.pdf

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a candidate hivaids vaccine (mva-b) lacking vaccinia virus gene c6l enhances memory hiv-1-specific t-cell responses候选人条件疫苗(mva-b)缺乏牛痘病毒基因c6l增强记忆hiv-1-specific t细胞反应

A Candidate HIV/AIDS Vaccine (MVA-B) Lacking Vaccinia Virus Gene C6L Enhances Memory HIV-1-Specific T-Cell Responses ´ 1 ´ ´ 1 ´ 1 1¤ 2 Juan Garcıa-Arriaza , Jose Luis Najera , Carmen E. Gomez , Nolawit Tewabe , Carlos Oscar S. Sorzano , 3 3 1 Thierry Calandra , Thierry Roger , Mariano Esteban * ´ ´ 1 Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologıa, Consejo Superior de Investigaciones Cientıficas (CSIC), Madrid, Spain, 2 Biocomputing ´ ´ Unit, Centro Nacional de Biotecnologıa, Consejo Superior de Investigaciones Cientıficas (CSIC), Madrid, Spain, 3 Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland Abstract The vaccinia virus (VACV) C6 protein has sequence similarities with the poxvirus family Pox_A46, involved in regulation of host immune responses, but its role is unknown. Here, we have characterized the C6 protein and its effects in virus replication, innate immune sensing and immunogenicity in vivo. C6 is a 18.2 kDa protein, which is expressed early during virus infection and localizes to the cytoplasm of infected cells. Deletion of the C6L gene from the poxvirus vector MVA-B expressing HIV-1 Env, Gag, Pol and Nef antigens from clade B (MVA-B DC6L) had no effect on virus growth kinetics; therefore C6 protein is not essential for vir