有哪些信誉好的足球投注网站a carrier for non-covalent delivery of functional beta-galactosidase and antibodies against amyloid plaques and igm to the brain的载体共价交付功能苷酶和淀粉样斑块和igm抗体到大脑.pdfVIP
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a carrier for non-covalent delivery of functional beta-galactosidase and antibodies against amyloid plaques and igm to the brain的载体共价交付功能苷酶和淀粉样斑块和igm抗体到大脑
A Carrier for Non-Covalent Delivery of Functional Beta- Galactosidase and Antibodies against Amyloid Plaques and IgM to the Brain 1,2 3 1 4 3 Gobinda Sarkar *, Geoffry L. Curran , Eric Mahlum , Teresa Decklever , Thomas M. Wengenack , 5 5 4 3 1 Anthony Blahnik , Bridget Hoesley , Val J. Lowe , Joseph F. Poduslo , Robert B. Jenkins * 1 Department of Experimental Pathology, Mayo Clinic, Rochester, Minnesota, United States of America, 2 Department of Orthopedics, Mayo Clinic, Rochester, Minnesota, United States of America, 3 Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America, 4 Department of Radiology, Mayo Clinic, Rochester, Minnesota, United States of America, 5 Tissue and Cell Molecular Analysis Laboratory, Mayo Clinic, Rochester, Minnesota, United States of America Abstract Background: Therapeutic intervention of numerous brain-associated disorders currently remains unrealized due to serious limitations imposed by the blood-brain-barrier (BBB). The BBB generally allows transport of small molecules, typically ,600 daltons with high octanol/water partition coefficients, but denies passage to most larger molecules. However, some receptors present on the BBB allow passage of cognate proteins to the brain. Utilizing such receptor-ligand systems, several investigators have developed methods for delivering proteins to the brain, a critical requirement of which involves covalent linking of the target protein to a carrier entity. Such covalent modifications involve extensive preparative and post- preparative chemistry that poses daunting limitations in the context of
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