有哪些信誉好的足球投注网站a case of convergence why did a simple alternative to canonical antibodies arise in sharks and camels的收敛为什么一个简单的替代规范抗体出现在鲨鱼和骆驼.pdfVIP
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a case of convergence why did a simple alternative to canonical antibodies arise in sharks and camels的收敛为什么一个简单的替代规范抗体出现在鲨鱼和骆驼
Unsolved Mystery A Case Of Convergence: Why Did a Simple Alternative to Canonical Antibodies Arise in Sharks and Camels? 1 2,3 2,3 Martin F. Flajnik , Nick Deschacht , Serge Muyldermans * 1 Department of Microbiology and Immunology, University of Maryland at Baltimore, Baltimore, Maryland, United States of America, 2 Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium, 3 Department of Molecular and Cellular Interactions, VIB, Brussels, Belgium Introduction and before the camel and llama speciation (,11 million years ago) (Figure 2) [6]. Also, the VHH germline genes descended from the The success of our adaptive humoral immune response, classical variable region of a heavy-chain (VH) genes, and the mediated by B cells, relies on its capacity to produce multiple diversity (D) and JH genes are even shared in the formation of the antigen-recognition specificities against any possible invader. This VH or VHH domains. Thus, the emergence of HCAbs was a antigen-recognition specificity is attributed to antibodies, which relatively recent event in these species. display remarkable flexibility and diversity. That diversity is In the nurse shark (Ginglymostoma cirratum), a novel secreted generated by cutting and pasting of immunoglobulin (Ig) gene
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