1.环氧环生成叠氮和羟基的反应2.端炔基羟基聚己内酯3.仲春羟基引发磷酸酯聚合.pdfVIP

8620 Macromolecules 2008, 41, 8620-8625 Synthesis of Amphiphilic ABC 3-Miktoarm Star Terpolymer by Combination of Ring-Opening Polymerization and “Click” Chemistry You-Yong Yuan,†,‡ Yu-Cai Wang,‡ Jin-Zhi Du,‡ and Jun Wang*,†,§ Hefei National Laboratory for Physical Sciences at Microscale, Department of Polymer Science and Engineering, and School of Life Sciences, Uni Versity of Science and Technology of China, Hefei, Anhui 230027, People’s Republic of China Recei Ved June 30, 2008; ReVised Manuscript ReceiVed September 28, 2008 ABSTRACT: Novel biodegradable amphiphilic ABC 3-miktoarm star terpolymers composed of poly(ε- caprolactone) (PCL), monomethoxy poly(ethylene glycol) (MPEG), and polyphosphoester (PPE) were synthesized by a combination of ring-opening polymerization and “click” chemistry. MPEG was first end-capped by epoxide ring, which was opened by sodium azide in the presence of ammonium chloride to give modified MPEG bearing reactive azide and hydroxyl groups (MPEG(-OH,-N3)). “Click” chemistry was then applied to conjugate R-propargyl-ω-acetyl-poly(ε-caprolactone) and MPEG(-OH,-N3), resulting in a diblock copolymer of MPEG and PCL with reactive hydroxyl groups at the junction point (MPEG(-OH)-b-PCL), which further initiated ring- opening polymerization of 2-ethoxy-2-oxo-1,3,2-dioxaphospholane (EEP) under the catalytic action of stannous octoate to obtain the desired well-defined (MPEG)(PCL)(PEEP) 3-miktoarm star terpolymers. Such terpolymers and their intermediates were characterized by 1H NMR, FT-IR, and gel permeation chromatography. These polymers are expected to be promising vehicles for dru