抗雄激素药物联合应用治疗女性中重度迟发型痤疮临床疗效评价.docVIP

抗雄激素药物联合应用治疗女性中重度迟发型痤疮临床疗效评价[摘要]目的：探讨抗雄激素药物联合应用治疗女性中重度迟发型痤疮的最佳方案和疗效。方法：将112例患者按完全随机设计法分成三组：治疗Ⅰ组采用达英-35联合小剂量甲泼尼龙口服，治疗Ⅱ组采用螺内酯联合小剂量甲泼尼龙口服，对照组采用维胺酯口服，4周为1个疗程，连续治疗12周后观察疗效及不良反应，治疗前后检测三组患者血清睾酮（T）、雌二醇(E2)。结果：12周后，治疗Ⅰ组有效率为73.7%，与对照组比较差异无统计学意义（P＞0.05）；治疗Ⅱ组有效率为41.2%，与对照组比较差异有统计学意义（P＜0.05）；治疗Ⅰ、Ⅱ组治疗前后血清T差异有统计学意义（P＜0.05），E2差异无统计学意义（P＞0.05）；对照组治疗前后T、E2差异均无统计学意义（P＞0.05）。结论：达英-35联合小剂量甲泼尼龙可有效治疗女性迟发型中重度痤疮。 [关键词]迟发型痤疮；抗雄激素；联用 [中图分类号]R758.73+3 [文献标识码]A [文章编号]1008-6455（2011）01-0095-03 Clinical effects evaluation of combination of different anti-androgen agents on severe delayed female acne LI Jie-si1，CHEN Lei-ning2，SU Xi-xiang1，LIU Zhen-feng1，LI Xue-ping1 (1.Department of dermatology, Shantou Dermatology Hospital, Shantou, Guangdong Province, 515041; 2.Department of gynaecology and obstetrics, Reproductive Medicine Center,Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, 510515) Abstract: Objective To investigate the best therapeutic strategies and clinical efficacy of combination of different anti-androgen agents on severe delayed female acne.MethodsA total of 112 patients with severe delayed female acne were divided into 3 groups by the completely random design with different anti-androgen agents. (Group I: Daine-35+Methylpredisolone; Group II:Sprionolactone + Methylpredisolone; Control group: Viaminate).The therapeutic effects and side effects were observed after 12-week treatments. The serum concentration of testosterone (T),estradiol(E2) were detected before and after treatment in these 3 groups.ResultsAfter 12-week treatments, the total effective rates of group I and group II were 73.7% and 41.2% respectively. There was no significant difference between group I and control group(P＞0.05) while the difference was statistically significant between group II and control group(P＜0.05). The serum testosterone level showed significantly difference(P＜0.05) and the serum estradiol level was similar (P＞0.05) before and after treatment in group I