Barrett食道及Barrett食管腺癌临床病理诊断及发生关系探究.docVIP

Barrett食道及Barrett食管腺癌临床病理诊断及发生关系探究[摘要]目的探讨Barrett食管与Barrett食管腺癌的临床病理诊断及发生关系。方法 收集我科Barrett食管31例，其中6例具有腺癌结构，根据纤维胃镜所见，组织学观察和粘液组化分析，结合临床资料进行分析。结果 31例Barrett食管AB-PAS、HID-AB粘液染色均呈阳性；6例食道腺癌中，5例癌旁有肠上皮化生，均为不完全型，肠型吸收上皮及贲门柱状上皮AB-PAS染色以红色和蓝色为主，HID-AB染色以黑色和蓝色为主。结论 本文认为慢性胃液返流使食管粘膜鳞状上皮长期受损，修复中，部分病例食管鳞状上皮由邻接耐酸性较强、增殖更活跃的胃贲门上皮向上异位生长而代替形成Barrett食管，长期非特异性刺激附加致癌因素，修复增生转变为渐近性异型增生，最终导致癌变。 [关键词]Barrett食管;Barrett食管腺癌； 粘液组化 [中图分类号] R73[文献标识码]A [文章编号] 1005-0515（2010）-10-001-01 Research of Barrett esophagus and barrett esophageal adenocarcinoma in Clinical and Pathological Diagnosis and Correlation occurred Luo xianyong,Zhang jiankun,Pang guolian,Li shengqiang （Department of Pathology, First People’s Hospital of Qujing city, Qujing city 655000） [Abstract]ObjectiveTo investigate the clinical and pathological diagnosis and relationship occurred in Barrett esophagus and Barrett esophageal adenocarcinoma.Methods The samples of 31 patients for Barrett esophagus were collected from Department of Pathology of First People’s Hospital of Qujing city.There are 6 patients with the structure of adenocarcinoma,Seen in the fiber gastroscope, Analyzed in histological, in mucus staining and clinical data.Results AB-PAS/HID-AB mucus were both positive in Barrett esophagus for 31 patients;In 6 cases of esophageal adenocarcinoma,there are 5 cases with intestinal metaplasia in adjacent,Are Incomplete type, absorption of AB-PAS staining mainly are red and blue,HID-AB staining mainly are black and blue on epithelial intestinal absorption and cardiac columnar epithelium.ConclusionThis paper argues that chronic gastric reflux damaged in esophageal squamous epithelium of esophageal mucosa for the long-term, repair, In some cases, esophageal squamous epithelium are insteaded of ectopic gastric cardia epithelial growth upward of the adjacent strong acid, added more active, to led to the formation of Barrett esophagus,non-specific stimulation for long-term caused additional carcinogenic factors, rep