d-二聚体评价溶栓治疗急性心肌梗塞的价值及意义（The value and significance of d- two dimer in the evaluation of thrombolytic therapy for acute myocardial infarction）.docVIP

d-二聚体评价溶栓治疗急性心肌梗塞的价值及意义（The value and significance of d- two dimer in the evaluation of thrombolytic therapy for acute myocardial infarction） Value and significance of D two in evaluating thrombolytic therapy for acute myocardial infarction 2010-11-12 and Yu Bin, Yu Yanqiu, Li Luguang, Zhang Guizhen, Li Yansun, Ya Li Thrombolytic therapy for acute myocardial infarction is through plasmin action in the thrombus in cross-linked fibrin, so that degradation, thereby achieving vascular recanalization. Fiber protein two dimer (D-Dimer) is a kind of specific degradation products of cross-linked fibrin thrombi in the degradation process, which in the serum concentration and in vivo thrombolysis is closely related, is an indicator of body fibrinolytic activity. We observed this. Materials and methods 1. clinical data: 59 patients with AMI were randomly selected, including 10 females and 49 males, aged 37~76 years (mean 56.5 years). The infarct: anterior wall in 23 cases, 17 cases of inferior wall, anterior wall in 11 cases, 3 cases of posterior wall, 5 cases of high side wall. 44 cases met the criteria of thrombolytic therapy and 15 cases were treated with non thrombolytic therapy (non thrombolysis). 2. methods: two groups of patients were treated before and after 1, 2, 4, 6, 8 hours, serum D-Dimer concentration (kit produced by Australia AGEN company, Latex method (g/L). Myocardial enzymes (CK, CK-MB), prothrombin time and activity were measured simultaneously. Among them, 43 cases were treated with urokinase 1 million 500 thousand units, and 1 cases with streptokinase 1 million 500 thousand units. The non thrombolytic group had the same treatment except for the absence of plasmin. The standard of curative effect was based on coronary angiography. There were 36 cases of thrombolysis group and 9 cases of non thrombolysis group. Coronary angiography was performed in TIMI group, and coronary artery patency was found. 3. statistical analysis: the data of each group were express