米诺迪尔（minoxidil）.docVIP

米诺迪尔（minoxidil） [general] name: 2% Minoxidil Solution [product name]: up Fei Yan English Name: Minoxidil Solution [Pinyin]: Minuodi of Er Rongye [the main ingredients are] 6- (1- piperidine), -2, -4- pyrimidine, two amines, 3- oxide. [its structure is]: Molecular formula C9H15N5O Molecular weight 209.25 [properties] colorless or light yellow transparent liquid [pharmacological toxicology]: minoxidil is a vasodilator around local, long-term use, can stimulate the male patients with alopecia and alopecia areata hair growth. The exact mechanism of this product for hair loss is unknown. The clinical study showed that normal blood pressure and untreated hypertensive patients when applied topically, did not show due to systemic effects caused by the absorption of minoxidil. Toxicological studies: there are no studies on animal toxicology at present. [pharmacokinetics] our country lacks the detailed pharmacokinetic data at present. According to foreign research data (RogaineTM) instructions, local application of Minoxidil Solution skin, the skin absorption of minoxidil is poor, while Minoxidil Tablets after oral administration, the gastrointestinal tract can be almost completely absorbed. 2% Minoxidil Solution 1ml per dose, 20mg can be transported to the skin results about minoxidil, minoxidil absorbed 0.28mg. 5% Minoxidil Solution 1ml per dose, 50mg can be transported to the skin results about minoxidil, minoxidil absorbed 0.70mg. Whether this absorption effect is associated with skin diseases is unknown. Minoxidil Solution after local administration, the plasma concentration of minoxidil by percutaneous drug absorption rate control. Stop the local application of Minoxidil Solution, the body absorbs about 95% minoxidil may be cleared within 4 days. Local application of RogaineTM after absorption of minoxidil metabolism, the transformation is not completely understood, but the oral absorption of minoxidil by N- oxygen glucuronic acid and piperidine ring on a combined into