C_反应蛋白与冠心病持续性房颤及心功能的关系_夏中华.pdfVIP

当代医学　2011年4月第17卷第11期总第238期　Contemporary Medicine, Apr. 2011,Vol.17 No.11 Issue No.238 doi:10.3969/j.issn.1009-4393.2011.11.004 C-反应蛋白与冠心病持续性房颤及心功能的关系 夏中华 杨月霞 黄文新 [摘要] 目的 探讨冠心病持续性房颤患者血清C反应蛋白（CRP）升高的临床意义及其与心功能的关系。方法 选择冠心病窦性心律患者30例，冠心病 持续性房颤患者60例，健康体检者20例作为正常对照组，采用酶联免疫双抗体夹心法测定三组患者的血清CRP水平。根据 NYHA 心功能分级标准，将房颤组患 结果 者分为四个亚组，比较各组的血清CRP水平。 血清CRP水平在房颤组[(7.44±1.59)ug/ml]高于窦律组[(6.38±1.09)ug/ml]和正常对照组[(3.04±0.91)ug/ml]， ＜0.05，具有统计学意义。冠心病窦性心律组和正常对照组比较，血清CRP水平亦显著升高( ＜0.05)。房颤组中，血清CRP水平在心功能Ⅰ级组与Ⅱ级组比较差 P P 异无统计学意义( ＞0.05)，在心功能Ⅳ级组[(9.10±0.89)ug/ml]可高于Ⅲ级组[(7.71±1.31)ug/ml]，Ⅲ级组亦高于Ⅱ级组[(6.26±1.08)ug/ml]，差异有统计学意义( P P 结论 ＜0.05)。 CRP增高与房颤有关，并且随着心功能不全程度的加重逐渐增高，提示炎症参与了房颤的发生、发展过程，可能在房颤的发病机制中起着重要的 作用。 [关键词] 心房颤动；C反应蛋白；炎症；心功能 [Abstract] Objective To investigate the clinical significance of CRP increasing in the CHD patients with persistent atrial fibrillation and the relationship with cardiac function. Methods 30 CHD patients with sinus rhythm and 60 CHD patients with persistent atrial Fibrillation were enrolled into this study. Twenty healthy people were taken as control group. Enzyme linked immunosorbent assay was used to detect the serum levels of C-reactive protein in these groups. According to the cardiac function stardand of New York Heart Association(NYHA), the CHD patients with persistent atrial fibrillation were divided into four groups, the levels of serum C-reactive protein were compared among the groups. Results The serum levels of C- reactive protein in persistent atrial fibrillation group [(7.40±1.57)ug/ml] were significantly higher than the sinus rhythm group[(6.26±0.97) 论