cTnI和CK—MB在窒息新生儿心肌损伤中的诊断价值.pdfVIP

Joumal of Medical Forum Vo1．29 No．5 March 2008 · 33· cTnI和CK—MB 在窒息新生儿 心肌损伤中的诊断价值 郭燕军 郑州市第三人民医院儿科 郑州市 450000 捅要 目的 探讨血清肌钙蛋白I(cTnI)和磷酸肌酸激酶同工酶(CK—MB)对窒息新生儿心肌损伤的 早期诊断价值。方法 选择轻度窒息新生儿4O例(轻度组)、重度窒息新生儿2O例(重度组)。采用ELISA法 和酶动力法检测新生儿血清TnI水平和CK—MB活性。结果 出生1d窒息新生儿血清cTnI和CK—MB水平在 轻度组和重度组均显著高于对照组(P0．O1)；重度组血清cTnl和CK—MB水平均显著高于轻度组(P O．O1)。治疗后7d窒息新生儿血清cTnI和CK—MB水平均明显下降，轻度组与对照组均无显著差异 (P O．o5)，重度组显著高于轻度组和对照组(P0．O1)。结论 窒息新生儿伴心肌损伤时血清cTnl和CK—MB水 平升高；动态观察可用于窒息新生儿微小心肌损伤的早期诊断。 关键词 心肌肌钙蛋白I；心肌损伤；窒息；婴儿；新生；磷酸肌酸激酶同工酶 中图分类号：R722．12 文献标识码：A 文章编号：1672-3422(20o8)05-0033-03 Study of Serum Cardiac Troponin I and Creatine Phosphokinase——Isoenzyme——MB in Asphyxia Nebnate GUO ranjun Department ofPediatrics，the Third People’S Hospital ofZhengzhou City，Zhengzhou 450002，China ABSTRACT 0bjective To explore the value of cardiac troponin I(cTnI)and creatine phos— phokinase—isoenzyme—MB(CK—MB)on early diagnosis of heart damage in asphyxia neonate． Methods A total of 60 cases of asphyxia neonates were divided into mild—asphyxia group(rt=40) and severe—asphyxia group(rt=20)，and the levels of cTnI and CK—MB were quantitatively deter- minated by ELISA and enzyme kinetics，respectively．Results Mter birth for the first day，the serum levels of cTnI and enzymatic activities of CK—-MB were all significantly higher in mild—-asphyxia group and severe—asphyxia group than those in control group(P0．O1)，and the results in severe— asphyxia group were significantly higher than those in mild—asphyxia group(Pa0．O1)．On the 7h day after treatment，the serum levels of cTnI and enzymatic activities of CK—MB were no significant differences between the mild—asphyxia gro