原子吸收分光光度法测定无机原料药中的有害元素-中国药事.PDF

496 2010 24 5 汪 麟, 于新颖, 刘天扬, 杨 杨, 庄舒翔, 姜连阁, 白政忠 ( , 150001) : 建立测定无机原料药铅镉汞铜4 种有害元素的原子吸收分光光度法铅镉采 用石墨炉法, 汞采用 吸收法, 铜采用火焰法标准曲线线性良好, 相关系数r 099, 加样回收 率在900%~ 1000% 之间, RSD 均小于70%该法专属性强简便易行灵敏度高, 可用于无机 原料药中有害元素的限量控制 : 原子吸收; 有害元素; 无机原料药 : R917 : :( 2010) Determination of Deleterious Elements in Inorganic Pharmaceutical Raw Materials by Atomic Absorption Spectrometry Wang Lin, Yu Xinying, Liu T ianyang, Yang Yang, Zhuang Shuxiang, Jiang Liange and Bai Zhengzhong (Heilongjiang Provincial Institute for Drug Control, Harbin 150001) ABSTRACT: bjective The method for the determination of deleterious elements ( lead, cadmium, mercury and cooper) in inorganic pharmaceutical raw materials by atomic absorption spectrometry was established. Methods Lead and cadmium were determined by graphite furnace method, mercury by cold absorption, copper by flame method. Results Standard curves were showed good linear; correlation coefficients ( r) were greater than 099; recovery rates were 900%~ 1000% ; each RSD was less than 70% . Conclusion The method is specific, simple and sensitive. It can be used in the limit control for harmful elements of inorganic pharmaceutical raw materials. KEY W RDS: atomic absorption spectrometry; deleterious elements; inorganic pharmaceutical raw materials , , 2005 7 ( , , [ 12] 2005 ) , , : 1 11 [34] , 6300 Unicorn ; ( 145mm ! , , 8mm) ; , , () , 12 : , , ; Email: situhong@ hotmailcom 2010 245 497 ( GSBG 6207190, : , 1 ; ( GSBG6204090, : , : ; ( GSBG 6206990, : ; 1 (GSBG 6202400, : ;