不同品种的升麻蜜制前后药理活性的比较.pdfVIP

呻善材 Journal of Chinese Medicinal Materials 第30卷第12期2007年12月 不同品种的升麻蜜制前后药理活性的比较 曹 丽，孙 虹，李 展，潘瑞乐 (中国医学科学院中国协和医科大学药用植物研究所，北京100094) 摘要 目的：比较不同品种升麻蜜制前后镇痛和镇静活性的差异。方法：采用小鼠福尔马林致痛反应、热板 法、醋酸扭体实验和小鼠自发活动及举双肢法观察升麻和兴安升麻生药和蜜制品的镇痛和镇静活性。结果：升麻 和兴安升麻蜜制品的镇痛和镇静活性均明显强于各自的生药。结论：不同品种升麻其镇痛和镇静活性经过蜜制后 显著增强。 关键词 升麻；兴安升麻；蜜制；镇痛；镇静 中图分类号：R285．5／R283．1 文献标识码：A 文章编号：1001 54(2007)12—1561-03 Comparison of Activities of Various Species of Rhizoma Cimicifugae and Their Honey Processed Products CAO Li，SUN Hong，LI Zhan．PAN Rui—le (Institute of Medicinal Plant Development，Chinese Academy of Medical Science，Peking Union Medical College，Beijing 100094， China) Abstract Objective：To compare the analgesic and sedative effects of various species of Rhizoma Cimicifugae and their processed products with honey． Methods：The three kinds of analgesic experiments of formalin，hot plate and writhing tests，and the number of spontaneous activities and raise forelimb s were adopted in mice．Results：All samples showed antinociceptive activities in the two pha— ses of formalin，tail immersion and writhing tests and sedative properties in the spontaneous locomotor activity test．The analgesic and sedative effects of processed Rhizoma Cimicifugae were higher than crude drugs．Conclusion：The present results demonstrate that the antinociceptive and sedative activity of sam ples processed with honey are more potent than crude drugs． Key words Cimicifuga foetida；Cimicifuga dahurica；Processed with honey；Analgesic activity；Sedative activity 升麻为常用中药，始载于《神农本草经》，列为 其蜜制前后的药理活性的变化进行研究，为升麻炮 上品，《本草纲目》归入草部山草类。2005年版中国 制的规范化研究及临床应用提供参考。 药典收载的升麻为毛茛科植物升麻(Cimicifuga foe— 1 材料 tida L．)、兴安升麻(C．dahurica Maxim．)和大三叶 1．1 实验动物 ICR小鼠，雌雄各半，20—22 g，购 升麻(C．heracleifolia Kom．)的根茎。