EBV相关性胃癌研究进展概要.PDFVIP

临床与病理杂志 2015, 35(12) J Clin Path ol R e s 2165 doi: 10.3978/j.issn.2095-6959.2015.12.030 View this article at: /10.3978/j.issn.2095-6959.2015.12.030 EBV相关性胃癌研究进展 黄贞 综述 张声 审校 (福建医科大学附属第一医院病理科，福州 350005) [摘　要] EB 病毒感染与胃癌的发生、发展关系密切。经原位杂交技术证实胃癌细胞EBER 阳性者称为EBV 相 关性胃癌，约占所有胃癌的 8.2% 。2014 年TCG A 根据分子表型将胃癌分为四种分子亚型：EBV 相 关性胃癌、微卫星不稳定型胃癌、基因稳定型胃癌和染色体不稳定型胃癌，开启胃癌靶向治疗新 时代。基于EBV 相关性胃癌的独特性，本文复习近年发表的相关文献，从流行病学、临床病理表 现、发病机制、治疗及预后等方面综述EBV 相关性胃癌的研究进展。 [关键词] EBV ；EBV 相关性胃癌；临床病理特征；发病机制 Research advance of EBV-associated gastric cancers HUANG Zhen, ZHANG Sheng (Department of Pathology, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China) Abstract Epstein-barr virus infection closely associated with the occurrence and development of gastric cancer. Epstein- barr virus-associated gastric carcinomas accounted for about 8.2% of all gastric cancers, in which EBER positive in cancer cell nucleus was confirmed by the in situ hybridization (ISH). In 2014 according to the molecular phenotype, TCGA divided gastric carcinomas into four subtypes: EBV-positive; microsatellite instability (MSI); genomically stable (GS) and chromosomally instability (CIN), which opened the new era of targeted therapies in the gastric carcinomas. Based on the uniqueness of its biological behavior, this paper reviewed the research advances about the epidemiology, clinical manifestation, histopathologic features, pathogenesis, treatment and prognosis of EBV-associated gastric cancers. Keywords EBV; EBV