肝细胞肝癌组织中Bcl-2核表达及MMP-2和MMP-9表达与术后复发转移及预后的关系.pdfVIP

202年第39卷第 期 中国肿瘤临床 769 肝细胞肝癌组织中Bcl-2核表达及MMP-2和MMP-9 表达与术后复发 转移及预后的关系* ① ①② ① ① ① ① ① 孙 涛 孙保存 赵秀兰 赵 楠 古 强 车 娜 董学易 池嘉栋① 探讨抗凋亡蛋白Bcl 2、基质金属蛋白酶 2（MMP 2）和MMP 9在肝细胞肝癌中表达的关联性，及其与复发、转 摘要 目的： 移和预后的关系。方法：以石蜡包埋组织切片，免疫组织化学SP法染色检测97例肝细胞肝癌，分别在复发与转移组49例和非复 发与转移组48例中分析Bcl 2核表达和MMP 2、MMP 9表达的情况。结果：复发与转移组Bcl 2核表达高于无复发与转移组 （χ2=7.912，P=0.005），复发转移组MMP 9表达高于无复发转移组（χ=6.545，P=0.011），Bcl 2核表达阳性细胞率与MMP 9阳性细2 胞率存在相关性，而与MMP 2无关。Bcl 2核表达组患者生存时间较短，差异具有统计学意义。 Bcl 2核表达阳性患者更 结论： 易出现复发与转移，且与MMP 9过度表达存在关联性，表明Bcl 2入核可能对肿瘤转移的相关生物学功能具有调节作用，可作为 评价HCC复发与转移、不良生存预后的候选临床标志。 关键词 Bcl 2 MMP 2 MMP 9 复发与转移 doi:10.3969/j.issn.1000 8179.2012.11.004 Relationship of Bcl-2 Expression with MMP2 and MMP9 Expression in Hepatocellular Carci- noma, and Their Correlation with Recurrence, Metastasis, and Prognosis Tao SUN , Baocun SUN ,2, Xiulan ZHAO , Nan ZHAO , Qiang GU , Na CHE , Xueyi DONG , Jiadong CHI Correspondence to: Baocun SUN; E mail: sunbaocun@ Department of Pathology, Tianjin Medical University, Tianjin 300070, China 2Department of Pathology, Cancer Institue and Hospital of Tianjin Medical University, Key Laboratory of Cancer Prevention and Treat ment of Tianjin City, Tianjin 300060, China This work was supported by the Key Program of the National Natural Science Foundation of China (No., the National Natu ral Science Foundation of China (No., and the Cooperation Project of China Sweden (No. 09ZCZDSF04400) Abstract Objective: To determine the correlation of the expression of the anti apoptotic protein Bcl 2 with the expression of matrix metalloproteinases MMP 2 a