O-季铵化改性壳聚糖固载环糊精的制备及其载药性能.pdfVIP

学兔兔 化 工 进 展 2010年第29卷第9期 CHEMICAL INDUSTRY AND ENGINEERING PROGRESS ·l705· 季铵化改性壳聚糖固载环糊精的制备及其载药性能 毛扬帆，李明春，辛梅华，谢钦钦 (华侨大学材料科学与工程学院，福建省高校功能材料重点实验室，福建 厦门361021) 摘 要：对壳聚糖进行O一季铵化改性，并与羧甲基移环糊精在均相条件下进行缩合反应，制得O．季铵化壳聚糖 固载环糊精 (QCSCD)，用FT 、EA和SEM对产物进行表征。以酮洛芬为模型药物，研究其载药及药物释放 行为。结果表明，季铵盐基团的引入提高了QCSCD的载药量，为3．97mg／mg，并且改变了QCSCD的pH响应 性能。与壳聚糖固载环糊精相反，QCSCD在模拟胃液中的释放速率很快，而在模拟肠液中具有缓释性能。 关键词：壳聚糖；季铵化；环糊精；载药性能 中图分类号：O 636．1 文献标志码：A 文章编号：1000—6613(2010)09—1705—05 Synthesis of O-quarternary ammonium chitosan bearing eyclodextrin and its controlled drug release MAOYangfan，LIMingchun，XINMeihua，XIEQinqin (College of Material Science and Engineering，Huaqiao University，The Key Laboratory for Function~Materials of Fujian Higher Education，Xiamen 361021，Fujian，China) Abstract：0一quartemary ammonium chitosan bearing carboxymethyl-fl-cyclodextrin(QCSCD)was synthesized by grafting carboxymethyl··p-cyclodextrin onto O-·quarternary ammonium chitosan in the presence of EDC and NHS．The structure of QCSCD was characterized by FTIR，EA and SEM．Using ketoprofen(KP)as a model drug，the release behavior of QCSCD in mimic gastric and intestinal solutions was investigated in comparison with that of chitosan bearing cyclodextrin(CSCD)． Experimental results indicated that QCSCD showed a higher drug—loading capacity with the maximum ketoprofen adsorption of 3．97 mg／mg．Compared with CSCD，QCSCD behaved an opposite pH responsibility and represented more stable release of the entrapped ketoprofen in mimic intestinal solution．These results suggested that QCSCD could be used as