血清CA199表达与阻塞性黄疸的相关性研究.docVIP

血清CA199表达与阻塞性黄疸的关联性研究 黄耀奎 王小忠 谢锷 汕头市中心医院（中山大学附属汕头医院），汕头，515031 【摘要】：目的：研究血清CA199表达与阻塞性黄疸的相关性。方法：CA199检测采用电化学发光法；血清胆红素采用钒酸盐氧化法。收集155例阻塞性黄疸患者的血清CA199与血清TBIL、DBIL、IBIL做统计学关联性研究。结果：（1）阻塞性黄疸患者血清中的CA199均不同程度的增高，并且随着DBIL值的升高呈上升趋势。（2）良性阻塞性黄疸患者血清中的CA199呈一过性增高，随着黄疸的消退，CA199大多可以回复正常。（3）血清CA199表达与DBIL关联性分析的Spearman秩相关系数ρS通过t检验P＜0.05,且ρS＞0。结论：血清CA199与阻塞性黄疸患者血清DBIL两个变量有直线正相关关系，但没有足够的证据说明两变量在生物学上存在因果关系。 【关键词】：CA199；阻塞性黄疸；相关性 Correlation Study on Serum CA199 expression and obstructive jaundice, HUANG Yao-kui, WANG Xiao-zhong.XIE E (Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou 515031,China) [Abstract]: Objective: To study the correlation of serum CA199 expression and obstructive jaundice. Methods: apply electrochemiluminescence to detect CA199; method; apply vanadate oxidation for serum bilirubin. Collected 155 obstructive jaundice patients’ serum CA199 and serum TBIL, DBIL, IBIL to conduct statistical correlation study. Outcomes: (1) CA199 of obstructive jaundice patients’ serum increased in different levels, and they increases with DBIL values rose. (2) in benign obstructive jaundice patients’ serum, the CA199 increase was transient; with the jaundice subsided, CA199 can mostly return to normal. (3) serum CA199 expression and correlation analysis DBIL Spearman rank correlation coefficient ρS tested by t, P 0.05, and ρS 0. Conclusion: Serum CA199 in patients with obstructive jaundice and DBIL, these two variables have positive linear correlation, but there is not enough evidence that the two variables have causal relationship in the biology. [Key words]: CA199; obstructive jaundice; correlation CA19-9作为肿瘤标志物在消化道肿瘤和其他系统肿瘤中具有较好的应用价值 [1]，但是临床上发现非肿瘤病例中梗阻性黄疸占47．05％。在黄疸病例中良、恶性病变相似，但在非肿瘤病例中梗阻性黄疸占76．19％且随黄疸的消退检测值下降[2]，目前对于CA199在阻塞性黄疸患者血清中的异常表达是否存在统计学的关联性，国内外尚未见报道。本研究旨在揭示CA199与阻塞性黄疸患者血清中胆红素是否存在统计学上的关联性，从而更好的评判CA199在阻塞性黄疸病因诊断中的应用价值。 资料与方法 1.1一般资料 收集2008年11月～2010年3月间汕头市中心医院收治的阻塞性黄疸患者的血清CA199和TBIL、DBIL、IBIL资料，筛选出合适研究资料。纳入条件：（1）出院诊断（包括主要诊断和次要诊断）为阻塞