非甾体抗炎药致上消化道出血的临床特征分析_庄俊雪.pdfVIP

现代药物与临床 Drugs Clinic 第 31 卷 第 7 期 2016 年 7 月 ·1107· 非甾体抗炎药致上消化道出血的临床特征分析 庄俊雪 1，潘 霖 2* 1. 天津市宝坻区人民医院，天津 301800 2. 天津市第一中心医院，天津 300192 摘 要：目的 分析非甾体抗炎药致上消化道出血的临床特征。方法 选取天津市第一中心医院 2012 年 10 月—2015 年 6 月消化道出血的住院患者 110 例，对其临床资料进行分析统计。按照出血前 10 d 内是否服用过非甾体抗炎药为标准对患者 进行分组，比较两组的临床特征。结果 两组患者在急性胃黏膜病变、胃底和胃窦胃溃疡、心血管病史以及前壁和后壁十二 指肠溃疡方面存在显著差异，两组比较具有统计学意义（P＜0.05）。其中用药组的急性胃黏膜病变、胃底和胃窦胃溃疡、心 血管病史所占比例大于非用药组，而用药组的前壁和后壁十二指肠溃疡所占比例小于非用药组。结论 在临床治疗过程中， 需要采取适当的措施有效地降低非甾体抗炎药所致的上消化道出血等不良反应。 关键词：非甾体抗炎药；上消化道出血；临床特征 中图分类号：R975 文献标志码：A 文章编号：1674 - 5515(2016)07 - 1107 - 03 DOI: 10.7501/j.issn.1674-5515.2016.07.042 Analysis on clinical characteristics of upper gastrointestinal bleeding induced by NSAIDs ZHUANG Jun-xue1, PAN Lin2 1. Baodi District People’s Hospital of Tianjin, Tianjin 301800, China 2. Tianjin First Center Hospital, Tianjin 300192, China Abstract: Objective To analyze the clinical characteristics of upper gastrointestinal bleeding induced by NSAIDs. Methods Inpatients (110 cases) with upper gastrointestinal bleeding in Tianjin First Center Hospital from November 2012 to June 2015 were selected, and the clinical data were retrospectively analyzed. The patients were divided into two groups according to the criterion whether taking NSAIDs in 10 d before bleeding, and the clinical characteristics between two groups were compared. Results There were significant difference in acute gastric mucosal lesion, gastric ulcer of fundus and antrum, a history of cardiovascular disease, and duodenal ulcer of antetheca and backwall between two groups (P 0.05). The proportion of acute gastric mucosal lesion, gastric ulcer of fundus, and antrum, and a history of cardiovascular disease in the drug group was higher than that in non-drug group.