硒对生殖的影响.PDF

2006 14 9 ? 1? ,, ( 山西医科大学细胞生物与遗传学教研室, 山西太原 030001) : 硒作为一个潜在的抗氧化 剂, 不仅 影响睾丸的形态和功能, 并影 响附睾内的 成熟精子 一 定剂量的硒 能拮抗 氟及重金属的生殖毒 性 硒不 足也是雌性流产的原因之一 : 硒; 硒蛋白; 生殖 : R 339 2 : A : 1006- 9534 ( 2006) 09- 0001- 02 1. ( 1) , , , , , , ( GPx ) - sG Px , GPx ( snG Px) ( G ST ) ( phGP x) ( TR ) G Px [ 1] , GST , G ST p hGPX , PX , phG PX ; phG ,, [ 1] SnGP x , , , TR , , TR[ 3] ( 2) , [ 1] phGPX , SnGP x SnGPx DNA [2] TR , , , K aur P , , ( : 山西医科大学基础医学院 学科 研究方向 建设基金 : 杨建一 , : ( 0. 02m g /kg ) , GST , ( 1m g /kg, ( 0. 2m g /kg) ? :, , DNA [1] # : ; , ! GPx ) DNA ; , , ,, ,, , D Behne ( 2~ 7 g/kg), 1, ;2 , ,4 , ,, ( 250~ 300 g /kg) , [ 4] ( 3) , , G a ry E [ 3] , , [ 3] , ;, ,, ;, [ 5] 2 , , , ,, ( 4) ? 2? ( 50m g /kg) , , K a takura M , G PX , [ 7] ( 3m g /kg) [ 6] ( 1. 4mg /kg ) , , , , , , , 2006 14 9 , , ; , 2. K um ar KS [ 8] , , 3. , , O ldereid N B , [ 9] W ayne [ 10] , , E VE, VB6 , dereid N B [ 9] NA 4. , , , [ 1] O l , mR [ 1 ] K aur P. E ffect of selen ium - induced oxidat ive stress on the cell k i net ics in testis and reprodu ct ive ab ility of m ale m ice [ J] . N u trition, 2005, 21 ( 3) : 351- 357. [ 2 ] Enn ing P. Iden tif icat ion of a sp ecific sperm nuclei selenoenzym e nec essary for p rotam in e th iol cross - link ing D uring sperm m atu ration [ J] . Faseb, 2001, 15: 1236 - 1239. [ 3 ] G ary E. Sequ ent ial developm en t of flagellar defects in sperm atid s and ep id idym al sperm atozoa of selen ium - deficien t rats [ J ] . R eproduc tion, 2004, 127: 335 - 342. [ 4] D Behne. E ffects of selenium deficiency on test icu lar m orpho logy and fun ct ion in rats[ J] . Journa l of R ep roduction and Fert ility, 1996, 106: 291- 297. [5] . DNA [ J] . , 2001, 35( 6 ) : 394- 396. [6] . [ J ]. , 1999, 26 ( 3) : 19 - 20. [ 7 ] K ataku raM. Preven tive effect of selen ium against the test icu lar in jury by cadm ium [ J] . N ippon E iseigaku Zassh,i 1999, 54 ( 2) : 481 - 489. [ 8 ] K um ar K s. R ole of red cel l selen ium in recurren t pregnan cy loss[ J]. Ob s