Numerical simulation of Franz diffusion experiment Application to drug loaded soft contact lenses.pdfVIP

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Numerical simulation of Franz diffusion experiment Application to drug loaded soft contact lenses.pdf

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Numerical simulation of Franz diffusion experiment Application to drug loaded soft contact lenses.pdf

Journal of Drug Delivery Science and Technology 38 (2017) 18e27 Contents lists available at ScienceDirect Journal of Drug Delivery Science and Technology journal homepage: /locate/jddst Numerical simulation of Franz diffusion experiment: Application to drug loaded soft contact lenses Kristinn Gudnason a, *, Svetlana Solodova b, Anna Vilardell c, Mar Masson b, Sven Sigurdsson a, Fjola Jonsdottir a a School of Engineering and Natural Sciences, University of Iceland, Iceland b Center of Pharmaceutical Research, University of Iceland, Iceland c Faculty of Pharmacy, University of Barcelona, Spain article info Article history: Received 14 September 2016 Received in revised form 20 December 2016 Accepted 20 December 2016 Available online 3 January 2017 Keywords: Drug loaded soft contact lens Ocular drug delivery Franz diffusion cell Controlled release abstract Drug loaded soft contact lenses (SCLs) have been considered as an alternative to drug administration via eye-drops to improve bioavailability and patient comfort. Understanding the drug delivery characteristics is key to the design of therapeutic drug delivery systems. In this study, Franz diffusion cell experiments were carried out in order to analyse such characteristics of hydrogel used in SCLs. Two types of experiments were carried out. In one case, the donor compartment was loaded with an initial concentration of diclofenac while in the other case the lens material was pre-loaded with diclofenac. Experiments were carried out with varied initial concentration and temperature. In order to simulate the experimental data and estimate relevant physical parameters of the SCL material, we introduce a general mathematical multi-layer model that takes into account diffusion within each layer as well as the effects of both partition and barriers between layers. The model includes a novel treatment of the discontinuity in drug concentration between layers in an accurate manner. We succeeded in simulating all these experime