Matrigel and Activin A promote cell-cell contact and anti-apoptotic activity in cultured human retinal pigment epithelium cells.pdfVIP

下载本文档

10
0
约6.49万字
约 13页
2017-04-11 发布于天津
举报
版权申诉

Matrigel and Activin A promote cell-cell contact and anti-apoptotic activity in cultured human retinal pigment epithelium cells.pdf

1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Matrigel and Activin A promote cell-cell contact and anti-apoptotic activity in cultured human retinal pigment epithelium cells.pdf

lable at ScienceDirect Experimental Eye Research 147 (2016) 37e49Contents lists avaiExperimental Eye Research journal homepage: www.elsevier .com/locate/yexerResearch articleMatrigel and Activin A promote cell-cell contact and anti-apoptotic activity in cultured human retinal pigment epithelium cells Xiaoling Guo a, Deliang Zhu a, Ruiling Lian c, Yuting Han c, Yonglong Guo a, Zhijie Li b, Shibo Tang d, **, Jiansu Chen a, b, c, * a Key Laboratory for Regenerative Medicine, Ministry of Education, Jinan University, Guangzhou 510632, China b Institute of Ophthalmology, Medical College, Jinan University, Jinan University, Guangzhou 510632, China c The Department of Ophthalmology, the First Clinical Medical College, Jinan University, Guangzhou 510632, China d Aier School of Ophthalmology, Central South University, Furong Middle Road 198#, Changsha 410015, Chinaa r t i c l e i n f o Article history: Received 10 October 2015 Received in revised form 12 March 2016 Accepted in revised form 25 April 2016 Available online 26 April 2016 Keywords: Human retinal pigmented epithelium Matrigel Activin A Cell-cell contact Anti-apoptosis* Corresponding author. Institute of Ophthalmology versity, West Huangpu Avenue 601#, Guangzhou 510 ** Corresponding author. E-mail addresses: tangsb@ (S. Tan (J. Chen). /10.1016/j.exer.2016.04.021 0014-4835/? 2016 Elsevier Ltd. All rights reserved.a b s t r a c t Age-related macular degeneration (AMD) is a leading cause of blindness among the aging population. Currently, replacement of diseased retinal pigment epithelium (RPE) cells with transplanted healthy RPE cells could be a feasible approach for AMD therapy. However, maintaining cell-cell contact and good viability of RPE cells cultured in vitro is difficult and fundamentally determines the success of RPE cell transplantation. This study was conducted to examine the role of Matrigel and Activin A (MA) in regu- lating cell-cell contact and anti-apoptotic activity in human RPE (hRPE) cells, as asse