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In vitro and in vivo evaluation of novel implantation technology in hydrogel contact lenses for controlled drug delivery.pdf

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In vitro and in vivo evaluation of novel implantation technology in hydrogel contact lenses for controlled drug delivery.pdf

Journal of Controlled Release 226 (2016) 47–56 Contents lists available at ScienceDirect Journal of Controlled Release journal homepage: /locate/jconrel In vitro and in vivo evaluation of novel implantation technology in hydrogel contact lenses for controlled drug delivery Furqan A. Maulvi a,?, Dhara H. Lakdawala a, Anjum A. Shaikh a, Ankita R. Desai a, Harsh H. Choksi a, Rutvi J. Vaidya a, Ketan M. Ranch a, Akshay R. Koli a, Bhavin A. Vyas a, Dinesh O. Shah b,c,d,e a Maliba Pharmacy College, Uka Tarsadia University, Surat 394350, India b Shah-Schulman Center for Surface Science and Nanotechnology, Dharmsinh Desai University, Nadiad 387001, India c Department of Chemical Engineering, University of Florida, Gainesville, FL 32611, United States d School of Earth and Environmental Sciences, Columbia University, New York, NY, United States e Department of Anaesthesiology, University of Florida, Gainesville, FL 32611, United States article info Article history: Received 28 December 2015 Received in revised form 25 January 2016 Accepted 5 February 2016 Available online 6 February 2016 Keywords: Timolol maleate Hydrogel contact lenses Ring implantation Controlled drug delivery Pharmacokinetic study Pharmacodynamic study abstract Glaucoma is commonly treated using eye drops, which is highly inef?cient due to rapid clearance (low residence time) from ocular surface. Contact lenses are ideally suited for controlled drug delivery to cornea, but incorporation of any drug loaded particulate system (formulation) affect the optical and physical property of contact lenses. The objective of the present work was to implant timolol maleate (TM) loaded ethyl cellulose nanoparticle-laden ring in hydrogel contact lenses that could provide controlled drug delivery at therapeutic rates without compromising critical lens properties. TM-implant lenses were developed, by dispersing TM encapsulated ethyl cellulose nanoparticles in acrylate hydrogel (fabricated as ring implant) and implanted th