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Activity of a melimine derived peptide Mel4 against Stenotrophomonas, Delftia, Elizabethkingia, Burkholderia and biocompatibility as a contact lens coating.pdf
G Model CLAE 938 No. of Pages 9
Contact Lens and Anterior Eye xxx (2016) xxx–xxx
Contents lists available at ScienceDirect
Contact Lens and Anterior Eye
journal homepage: /locate/clae
Activity of a melimine derived peptide Mel4 against Stenotrophomonas, Delftia, Elizabethkingia, Burkholderia and biocompatibility as a contact lens coating
Debarun Duttaa,*, Timothy Zhaoa, Kai Bing Cheaha, Larke Holmlundb, Mark D.P. Willcoxa
a School of Optometry and Vision Science, University of New South Wales, Australia b Department of Biology, University of Copenhagen, Denmark
ARTICLE INFO
Article history: Received 6 October 2016 Received in revised form 12 December 2016 Accepted 10 January 2017
Keywords: Antimicrobial Contact lens Melimine Mel4 Delftia Stenotrophomonas
ABSTRACT
Purpose: To determine the antimicrobial activity of the melimine derived peptide Mel4 against Delftia, Stenotrophomonas, Elizabethkingia, Burkholderia and to investigate biocompatibility of Mel4 as an antimicrobial coating on contact lenses in animals and humans. Methods: In vitro antimicrobial activity of Mel4 was determined against the four Gram negative bacteria by investigating growth curves for 24 h followed by viable counts to determine the minimum inhibitory concentration (MIC). Contact lenses were coated by covalently binding Mel4, characterized by amino acid analysis, and were investigated for changes in lens parameters. Safety of Mel-4 coated lenses were determined in a rabbit model of daily contralateral wear. A prospective, randomised, double-masked, contralateral, 1week daily wear human clinical trial was used to evaluate subjective responses and ocular physiology.
Results: Mel4 was active against all the bacteria tested (MIC50 ranged from 31–1000 mg mlà1) and
produced an antimicrobial surface on contact lenses. Mel4-coating resulted hydrophilic surface without any signi?cant change in contact lens parameters, and showed no signs of cytotoxicity or ocular irritation during rabbit wear. During h
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