斑蝥酸钠维生素B6联合参芪扶正注射液对晚期恶性肿瘤患者生活质量研究.docVIP

斑蝥酸钠维生素B6联合参芪扶正注射液对晚期恶性肿瘤患者生活质量研究 牛丽娟 李涛 关丽云1 河北省医学科学研究重点课题计划项目 课题号【摘要】目的 探讨斑蝥酸钠维生素B6注射液联合参芪扶正注射液对晚期恶性肿瘤患者生活质量的影响。方法60例晚期恶性肿瘤患者随机分为两组，对照组30 例，给予参芪扶正注射液 (丽珠集团生产，250mL/瓶)250 mL静脉点滴。每日1次，同时给予对症及营养支持治疗；治疗组30例，在上述的基础上加用斑鳌酸钠维生素B6注射液(贵州柏强制药有限公司，每支含斑鳌酸钠维生素0.05mg、维生素B6 1.25mg，5毫升/支) 40毫升加人0.9%氯化钠注射液250毫升静脉点滴，每日 1 次。连用21天，间隔1周后重复使用，28天为1疗程。两组共完成 3个疗程后进行评估。结果 治疗组与对照组在KPS评分、体重、QOL评分变化等指标的差异有统计学意义（P0.05），且治疗组1年生存率略长于对照组，不良反应发生少。结论 斑蝥酸钠维生素B6和参芪扶正注射液联合使用能明显改善晚期肿瘤患者的生活质量，效果优于参芪扶正注射液单药，不良反应少，适用范围广，值得临床推广。 【关键词】斑蝥酸钠维生素B6；参芪扶正注射液；恶性肿瘤；生活质量 Sodium Cantharidinate and Vitamin B6 Injection combined Shenqi Fuzheng Injection improve quality of life in patients with Late Malignant Tumor Niu LiJuan1 ,Li tao2 ,Guan LiYun1 Key project in hebei province Medical scientific research project number: 【abstract】objective Explore the quality of life of the patients with late malignant tumor, influence of treatments of Sodium Cantharidinate and Vitamin B 6 Injection combined Shenqi Fuzheng Injection.Methods 60 patients with late malignant tumor were randomly divided into two groups, control group 30 cases, given Shenqi Fuzheng Injection (Lizhu group production, 250 mL/bottle) 250 mL intravenous drip. 1 times per day, and at the same time give symptomatic and nutritional support treatment; Treatment group 30 cases, on the basis of the above, plus Sodium Cantharidinate and Vitamin B6 Injection (Guizhou boqiang pharmaceutical co.LTD. each containing Sodium Cantharidinate and Vitamin 0.05 mg, 1.25 mg, vitamin B6 5ml/a) , 250 ml of 0.9% sodium chloride injection added in 40 ml, 1 times a day. Application for 21 days, repeated use after two weeks, 28 days for 1 course of treatment. After 3 course of, two groups were evaluated. Results In the KPS score, the difference of the index such as body weight, QOL score,the change of treatment group and control group was statistically significant (P 0.05). treatment group抯t 1 year survival rate is slightly longer than the control g