盐酸戊乙奎醚联合血液灌流救治重度有机磷中毒效果分析.docVIP

盐酸戊乙奎醚联合血液灌流救治重度有机磷中毒效果分析 　　[摘 要] 目的：探讨重度急性有机磷中毒应用血液灌流联合盐酸戊乙奎醚临床价值。方法：选取2010年1月-2012年12月我院收治的急性重度有机磷中毒患者70例，根据治疗方法分为两组，对照组在有机磷中毒常规治疗基础上予盐酸戊乙奎醚注射液注射，观察组在此基础上予HP治疗，比较两组治疗前、治疗后2h、6h血ChE活力，ChE复常时间、患者中毒症状消失时间、并发症发生率及病死率。结果：治疗前两组患者胆碱酯酶活力相比无显著差异（P0.05），治疗后2h、6hChE恢复情况及ChE复常时间观察组均显著优于对照组（P0.05）。观察组患者中毒症状消失时间相比对照组显著缩短（P0.05），观察组中间综合征、呼吸衰竭等并发症发生率、病死率显著低于对照组（P0.05）。结论：盐酸戊乙奎醚联合血液灌流治疗重度有机磷中毒，可缩短胆碱酯酶活性恢复时间及住院天数，减少中间综合征、呼吸衰竭等并发症的发生率，提高治愈率。 　　[关键词] 盐酸戊乙奎醚；血液灌流；重度有机磷中毒 　　中图分类号： R 459.7 文献标识码： A 文章编号：2095-5200（2015）04-087-03 　　[Abstract] Objective： To observe the clinical value of penehyclidine hydrochloride combined with hemoperfusion treating acute severe organophosphorus pesticide poisoning. Methods： From 2010.1 to 2012.12， 70 patients with acute severe organophosphorus pesticide poisoning in our hospital were selected and divided into two groups according to treatment methods. The control group was given penehyclidine hydrochloride on the basis of conventional treatment， while the observation group was treated with hemoperfusion basis on the control， comparing activity and recovery time of ChE， extinction time of poisoning symptoms， offline time of respiration， complication probability and death rate before and after treatment for 2 hour and 6 hour. Results： Cholinesterase activity in two groups were not significant difference before treatment（P0.05）， 2h and 6h after treatment， activity and recovery time of ChE were obviously superior to control（P0.05）. The remission time of poisoning symptoms， offline period and length of stay of the observation group was evidently shorter than that of the control group（P0.05）， complication including intermediate syndrome， respiratory failure and so on ， and the death rate reduced evidently（P0.05）. Conclusion： Penehyclidine hydrochloride combined with hemoperfusion treating acute severe organophosphorus pesticide poisoning short the recovery process of cholinesterase activity， offline period and length of stay， while reducing complicatio