发生基本听力障碍时神经递质改变的必威体育精装版观点.docVIP

发生基本听力障碍时神经递质改变的必威体育精装版观点 耳鸣可将中低到中等强度的不舒服声音视为响亮声音。近20％的美国人口患有耳鸣，耳鸣已经被报道是所有美国老兵最普遍的服役残疾。许多类型的周围损伤都会诱导耳鸣或听觉过敏，包括由强烈声音或耳毒性药物引起的耳蜗损伤和破坏听觉神经的耳蜗消融或神经切断，但我们对这些听力发展障碍的病理生理机制却知之甚少。为了进一步阐明发病机制，需要更好地理解周围损伤后的兴奋性和抑制性信号再平衡机制。美国托莱多大学医学院Donald A. Godfrey教授在《中国神经再生研究（英文版）》杂志2015年3月第3期发表的关于中枢听觉系统中耳蜗损伤的观点文章中提出，对耳鸣的听觉过敏提出化学损伤在这一领域可能实属首次。作者认为现在或许是研究者们商定一个更规范的，以化学作用进行分类中枢听觉系统后耳蜗损害术语的一个好时机。 Article: Current view of neurotransmitter changes underlying tinnitus by Augustine C. Lee, Donald A. Godfrey Department of Neurology, University of Toledo College of Medicine, Toledo, OH, USA; Division of Otolaryngology and Dentistry, Department of Surgery, University of Toledo College of Medicine, Toledo, OH, USA Lee AC, Godfrey DA 2015 Current view of neurotransmitter changes underlying tinnitus. Neural Regen Res 10 3 :368-370. 欲获更多资讯：Neural Regen Res Current view of neurotransmitter changes underlying hearing disorders Tinnitus is the perception of a monotonous sound not present in the environment, and hyperacusis is an auditory hypersensitivity disorder in which low to moderate intensity sounds are uncomfortably perceived as loud sounds. Nearly 20% of the US population suffers from tinnitus, and tinnitus has been reported to be the most prevalent service-connected disability of all U.S. veterans. Many types of peripheral injury have been understood to induce tinnitus or hyperacusis, including damage to the cochlea by intense sound or ototoxic medications and destruction of the auditory nerve by cochlear ablation or nerve transection. The pathophysiological mechanisms by which these hearing disorders develop are only poorly understood. In order to further clarify the pathogenesis, a need has been expressed for a better understanding of the rebalancing of excitatory and inhibitory signaling mechanisms that occur after peripheral injury. To the best of our knowledge, Prof. Donald A. Godfrey’s review of the current scientific literature concerning the effects of cochlear damage on chemistry in the centr