Pregnancy outcomes in women with growth hormone deficiency》.pdfVIP

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Pregnancy outcomes in women with growth hormone deficiency》.pdf

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Pregnancy outcomes in women with growth hormone deficiency》.pdf

ORIGINAL ARTICLE: ENVIRONMENT AND EPIDEMIOLOGY Pregnancy outcomes in women with growth hormone deﬁciency Greisa Vila, M.D.,a Ann-Charlotte Akerblad, Ph.D.,b Anders F. Mattsson, Ph.D.,b Michaela Riedl, M.D.,a c d e f Susan M. Webb, Ph.D., Vaclav Hana, M.D., Eigil H. Nielsen, Ph.D., Beverly M. K. Biller, M.D., and Anton Luger, M.D.a a Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria; b Pﬁzer Endocrine Care, Sollentuna, Sweden; c IIB-Sant Pau and Service of Endocrinology, Department of Medicine, Centro de Investigacion Biomedica en Enfermedades Raras (CIBER-ER Unidad 747), Hospital Sant Pau, d Third Department of Internal Medicine, First Faculty of Universitat Autonoma de Barcelona, Barcelona, Spain; Medicine, Charles University, Prague, Czech Republic; e Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark; and f Neuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts Objective: To study pregnancies in a large group of patients with growth hormone deﬁciency and hypopituitarism; and to investigate potential factors determining pregnancy outcomes and pregnancy complications. Design: We analyzed pregnancies reported in KIMS, the Pﬁzer International Metabolic Database, of adult patients with growth hor- mone deﬁciency treated with growth hormone. Setting: Outpatient clinics. Patient(s): A total of 201 pregnancies were reported: 173 in female patients and 28 in partners of male patients. Intervention(s): Growth hormone replacement therapy (GHRT) was prescribed accordin