Opisthorchiasis and Opisthorchis-associated cholangiocarcinoma in Thailand and Laos》.pdfVIP

Acta Tropica 120S (2011) S158–S168 Contents lists available at ScienceDirect Acta Tropica j o u r n a l h o m ep a g e : w w w. elsev /locate / a c t atr o p ica Review Opisthorchiasis and Opisthorchis-associated cholangiocarcinoma in Thailand and Laos Banchob Sripa a,∗ , Jeffrey M. Bethony b , Paiboon Sithithaworn c , Sasithorn Kaewkes c , Eimorn Mairiang d , Alex Loukas e , Jason Mulvenna e , Thewarach Laha c , Peter J. Hotez b , Paul J. Brindley b,∗∗ a Tropical Disease Research Laboratory (TDR), Department of Pathology, Khon Kaen University, Khon Kaen 40002, Thailand b Department of Microbiology, Immunology Tropical Medicine, George Washington University Medical Center, Washington, DC 20037, USA c Department of Parasitology, Khon Kaen University, Khon Kaen 40002, Thailand d Department of Radiology, Khon Kaen University, Khon Kaen 40002, Thailand e Queensland Tropical Health Alliance, James Cook University, Cairns, Queensland 4878, Australia a r t i c l e i n f o a b s t r a c t Article history: Liver fluke infection caused by Opisthorchis viverrini is a major public health problem in Thailand and Available online 23 July 2010 the Lao People’s Democratic Republic (Lao PDR; Laos). Currently, more than 600 million people are at risk of infection with these fish-borne trematodes and/or their close relatives. Opisthorchiasis has been Keywords: studied extensively