mTOR Inhibition Ameliorates Cognitive and Affective Deficits Caused by Disc1 Knockdown in Adult-Born Dentate Granule Neurons》.pdfVIP

Neuron Report mTOR Inhibition Ameliorates Cognitive and Affective Deficits Caused by Disc1 Knockdown in Adult-Born Dentate Granule Neurons Miou Zhou,1,10 Weidong Li,1,2,3,10,* Shan Huang,1 Juan Song,6,7,8 Ju Young Kim,6,7 Xiaoli Tian,4 Eunchai Kang,6,7 Yoshitake Sano,1 Cindy Liu,6,7 J. Balaji,1 Shumin Wu,5 Yu Zhou,1,9 Ying Zhou,2,3 Sherveen N. Parivash,1 Dan Ehninger,1,11 Lin He,2 Hongjun Song,6,7,8 Guo-li Ming,6,7 and Alcino J. Silva1,* 1Departments of Neurobiology, Psychology, and Psychiatry, Integrative Center for Learning and Memory and Brain Research Institute, UCLA, Los Angeles, CA 90095, USA 2Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, China 3Wuxi Mental Health Center, 156 Qian Rong Road, Wuxi 214151, China 4Division of Pulmonary and Critical Care Medicine 5Department of Molecular and Medical Pharmacology David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA 6Institute for Cell Engineering 7Department of Neurology 8Human Genetics Program Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA 9Department of Physiology, Medical College of Qingdao University, Qingdao 266071, China 10These authors contributed equally to this work 11Present address: DZNE, German Center for Neurodegenerative Diseases, Ludwig-Erhard-Allee 2, 53175 Bonn, Germany *Correspondence: liwd@ (W.L.), silvaa@ (A.J.S.) /10.1016/j.neuron.2012.12.033 SUMMARY et al., 2008b). However, developmental processes, such as neuronal progenitor cell proliferation, migration, and differentia- Abnormalities during brain development are thought tion, continue throughout life in defined brain cell populations, to cause psychiatric illness and other neurodevelop-