MRI in diagnosis of pathological complete response in breast cancer patients after neoadjuvant chemotherapy》.pdfVIP

European Journal of Radiology 84 (2015) 242–249 Contents lists available at ScienceDirect European Journal of Radiology j o u r na l h o me p ag e: w w w. elsev /locate/ejr ad MRI in diagnosis of pathological complete response in breast cancer patients after neoadjuvant chemotherapy Yan-Ling Li, Xiao-Peng Zhang, Jie Li, Kun Cao, Yong Cui, Xiao-Ting Li, Ying-Shi Sun ∗ Department of Radiology, Peking University Cancer Hospital Institute, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education),Beijing, China a r t i c l e i n f o a b s t r a c t Article history: Objective: To select effective indicators for diagnosis of pathological complete response (pCR) by MRI and Received 5 June 2014 to establish an appropriate diagnostic program to maximize the accuracy of pCR detection by MRI. Accepted 24 November 2014 Materials and methods: Twenty-one pCR patients and 22 non-pCR randomly selected patients receiving neoadjuvant chemotherapy (NAC) and subsequent surgery were recruited for the study. All patients Keywords: underwent breast MRIs both before and after chemotherapy. Changes in diameter, area and dynamic Magnetic resonance imaging variables between the first and final MRI were compared between the two groups. Logistic and ROC Breast cancer analysis were performed to select effective indicators for predicting pCR on MRI. Neo-adjuvant chemotherapy Results: Eleven out of