NMDA and D1 receptors are involved in one-trial tolerance to the anxiolytic-like effects of diazepam in the elevated plus maze test in rats》.pdfVIP

Pharmacology, Biochemistry and Behavior 135 (2015) 40–45 Contents lists available at ScienceDirect Pharmacology, Biochemistry and Behavior journal homepage: www. /locate/pharmbiochembeh NMDA and D1 receptors are involved in one-trial tolerance to the anxiolytic-like effects of diazepam in the elevated plus maze test in rats Heng Zhou a,b, Cheng-Long Yu a,b, Li-Ping Wang b, Yue-Xiong Yang b, Rong-Rong Mao b, Qi-Xin Zhou b,⁎, Lin Xu a,b,c,⁎⁎ a School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China b Laboratory of Learning and Memory, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, CAS, Kunming 650223, China c CAS Center for Excellence in Brain Science, 320 Yue Yang Road, Shanghai 200031, China a r t i c l e i n f o a b s t r a c t Article history: The elevated plus maze (EPM) test is used to examine anxiety-like behaviors in rodents. One interesting phe- Received 4 December 2014 nomenon in the EPM test is one-trial tolerance (OTT), which refers to the reduction in the anxiolytic-like effects Received in revised form 14 May 2015 of benzodiazepines when rodents are re-exposed to the EPM. However, the underlying mechanism of OTT is still Accepted 15 May 2015 unclear. In this study, we reported that OTT occurred when re-exposure to the EPM (trial 2) only depended on the Available online 21 May 2015 prior experience of the EPM (trial 1) rather than diazepam treatment. This process was memory-dependent, as it was prevented by