Non-invasive screening of HLA-DPA1 and HLA-DPB1 alleles for persistent hepatitis B virus infection Susceptibility for vertical transmission and toward a personalized approach for vaccination and treatment》.pdfVIP

Clinica Chimica Acta 412 (2011) 952–957 Contents lists available at ScienceDirect Clinica Chimica Acta jour nal homepage: www. /locate/clinchim Non-invasive screening of HLA-DPA1 and HLA-DPB1 alleles for persistent hepatitis B virus infection: Susceptibility for vertical transmission and toward a personalized approach for vaccination and treatment Kin-Chong Lau a, Ching-Wan Lam a,⁎, Chun-Yiu Law b, Sik-To Lai c, Tak-Yin Tsang c, Carol Wai-Kwan Siu b, Wing-Kin To d, Ka-Fai Leung a, Chloe Miu Mak b, Wing-Tat Poon b, Paul Kay-Sheung Chan e, Yan-Wo Chan b a Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China b Department of Pathology, Princess Margaret Hospital, Hong Kong, China c Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, China d Department of Pathology, Kowloon West Cluster, Hong Kong, China e Department of Microbiology, The Chinese University of Hong Kong Prince of Wales Hospital, Hong Kong, China a r t i c l e i n f o a b s t r a c t Article history: Background: Polymorphisms in the major histocompatibility complex (MHC) and non-MHC genes were Received 3 September 2010 recently reported to be associated with persistent hepatitis B virus (HBV) infection and host response to Received in revised form 24 January 2011 hepatitis B vaccine in Asian populations. We aimed to confirm the associations in Chinese population and Accepted 24 January 2011 develop a non-invasive screening method for the risk loci. Available online 16 February 2011