Mechanism by which ma-xing-shi-gan-tang inhibits the entry of influenza virus》.pdfVIP

Journal of Ethnopharmacology 143 (2012) 57–67 Contents lists available at SciVerse ScienceDirect Journal of Ethnopharmacology journal homepage: /locate/jep Mechanism by which ma-xing-shi-gan-tang inhibits the entry of influenza virus Chung-Fan Hsieh a, Cheng-wei Lo a, Chih-Hao Liu b, Shiming Lin b, Hung-Rong Yen c, Tzou-Yien Lin d, Jim-Tong Horng a,e,f,n a Graduate Institute of Biomedical Sciences, Chang Gung University, Kweishan, Taoyuan 333, Taiwan b Institute of Applied Mechanics, College of Engineering, National Taiwan University, Roosevelt Road, Taipei 106, Taiwan c Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan d Division of Pediatric Infectious Disease, Department of Pediatrics, Chang Gung Children’s Hospital, Taoyuan 333, Taiwan e Department of Biochemistry, Chang Gung University, 259 Wen-Hwa First Road, Kweishan, Taoyuan 333, Taiwan f Research Center for Emerging Viral Infections, Chang Gung University, Kweishan, Taoyuan 333, Taiwan a r t i c l e i n f o a b s t r a c t Article history: Ethnopharmacological relevance: Ma-xing-shi-gan-tang (MXSGT, aka maxing shigan powder), a Chinese Received 13 February 2012 herbal decoction, has been used for the treatment of the common cold, fever, and influenza virus Received in revised form infections. However, the underlying mechanisms of its activity against the influenza virus are not fully 30 April 2012 understood. In this study, we examined the antiviral effects of MXSGT in influenza-virus-infected Ac