Large Isoform of Mammalian Relative of DnaJ is a Major Determinant of Human Susceptibility to HIV-1 Infection》.pdfVIP

EBioMedicine 1 (2014) 126–132 Contents lists available at ScienceDirect EBioMedicine j ournal homepage: Original Article Large Isoform of Mammalian Relative of DnaJ is a Major Determinant of Human Susceptibility to HIV-1 Infection Yu-Ping Chiang a,1, Wang-Huei Sheng b,1, Pei-Lan Shao a,1, Ya-Hui Chi c,1, Yi-Ming Arthur Chen d, Szu-Wei Huang d, Hsiu-Ming Shih e, Luan-Yin Chang a, Chun-Yi Lu a, Shan-Chwen Chang b, Chien-Ching Hung b, Li-Min Huang a,⁎ a Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan b Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan c Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 350, Taiwan d Center for Infectious Diseases and Cancer Research (CICAR), Kaohsiung Medical University, Kaohsiung, Taiwan e Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan a r t i c l e i n f o s u m m a r y Article history: Individual differences in susceptibility to human immunodeficiency virus type 1 (HIV-1) infection have been of Received 5 September 2014 interest for decades. We aimed to determine the contribution of large isoform of Mammalian DnaJ (MRJ-L), a Received in revised form 6 October 2014 HIV-1 Vpr-interacting cellular protein, to this natural variation. Expression of MRJ-L in monocyte-derived macro- Accepted 6 October 2014 phag